Dynamic changes of muscle insulin sensitivity after metabolic surgery

Sofiya Gancheva, Meriem Ouni, Tomas Jelenik, Chrysi Koliaki, Julia Szendroedi, Frederico G. S. Toledo, Daniel F. Markgraf, Dominik H. Pesta, Lucia Mastrototaro, Elisabetta Filippo, Christian Herder, Markus Jähnert, Jürgen Weiss, Klaus Strassburger, Matthias Schlensak, Annette Schürmann and Michael Roden ()
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Sofiya Gancheva: Heinrich-Heine University
Meriem Ouni: German Center for Diabetes Research (DZD e.V.)
Tomas Jelenik: Heinrich Heine University
Chrysi Koliaki: Heinrich-Heine University
Julia Szendroedi: Heinrich-Heine University
Frederico G. S. Toledo: University of Pittsburgh School of Medicine
Daniel F. Markgraf: Heinrich Heine University
Dominik H. Pesta: Heinrich Heine University
Lucia Mastrototaro: Heinrich Heine University
Elisabetta Filippo: Heinrich Heine University
Christian Herder: Heinrich-Heine University
Markus Jähnert: German Center for Diabetes Research (DZD e.V.)
Jürgen Weiss: German Center for Diabetes Research (DZD e.V.)
Klaus Strassburger: German Center for Diabetes Research (DZD e.V.)
Matthias Schlensak: Schön Clinics
Annette Schürmann: German Center for Diabetes Research (DZD e.V.)
Michael Roden: Heinrich-Heine University

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respiratory control ratio. Persistent elevation of intramyocellular lipid intermediates, likely resulting from unrestrained adipose tissue lipolysis, accompanies the lack of rapid changes in insulin sensitivity. Simultaneously, alterations in skeletal muscle expression of genes involved in calcium/lipid metabolism and mitochondrial function associate with subsequent distinct DNA methylation patterns at 52 weeks after surgery. Thus, initial unfavorable metabolic changes including insulin resistance of adipose tissue and skeletal muscle precede epigenetic modifications of genes involved in muscle energy metabolism and the long-term improvement of insulin sensitivity.

Date: 2019
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DOI: 10.1038/s41467-019-12081-0

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