The fecal resistome of dairy cattle is associated with diet during nursing

Jinxin Liu, Diana H. Taft, Maria X. Maldonado-Gomez, Daisy Johnson, Michelle L. Treiber, Danielle G. Lemay, Edward J. DePeters and David A. Mills ()
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Jinxin Liu: University of California, Davis
Diana H. Taft: University of California, Davis
Maria X. Maldonado-Gomez: University of California, Davis
Daisy Johnson: University of California, Davis
Michelle L. Treiber: University of California, Davis
Danielle G. Lemay: USDA ARS Western Human Nutrition Research Center
Edward J. DePeters: University of California, Davis, California
David A. Mills: University of California, Davis

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Antimicrobial resistance is a global public health concern, and livestock play a significant role in selecting for resistance and maintaining such reservoirs. Here we study the succession of dairy cattle resistome during early life using metagenomic sequencing, as well as the relationship between resistome, gut microbiota, and diet. In our dataset, the gut of dairy calves serves as a reservoir of 329 antimicrobial resistance genes (ARGs) presumably conferring resistance to 17 classes of antibiotics, and the abundance of ARGs declines gradually during nursing. ARGs appear to co-occur with antibacterial biocide or metal resistance genes. Colostrum is a potential source of ARGs observed in calves at day 2. The dynamic changes in the resistome are likely a result of gut microbiota assembly, which is closely associated with diet transition in dairy calves. Modifications in the resistome may be possible via early-life dietary interventions to reduce overall antimicrobial resistance.

Date: 2019
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DOI: 10.1038/s41467-019-12111-x

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