Near-infrared light and tumor microenvironment dual responsive size-switchable nanocapsules for multimodal tumor theranostics

Zhiyi Wang, Yanmin Ju, Zeeshan Ali, Hui Yin, Fugeng Sheng (), Jian Lin, Baodui Wang () and Yanglong Hou ()
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Zhiyi Wang: Peking University
Yanmin Ju: Peking University
Zeeshan Ali: Peking University
Hui Yin: Chinese PLA General Hospital
Fugeng Sheng: Chinese PLA General Hospital
Jian Lin: Peking University
Baodui Wang: Lanzhou University
Yanglong Hou: Peking University

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Smart drug delivery systems (SDDSs) for cancer treatment are of considerable interest in the field of theranostics. However, developing SDDSs with early diagnostic capability, enhanced drug delivery and efficient biodegradability still remains a scientific challenge. Herein, we report near-infrared light and tumor microenvironment (TME), dual responsive as well as size-switchable nanocapsules. These nanocapsules are made of a PLGA-polymer matrix coated with Fe/FeO core-shell nanocrystals and co-loaded with chemotherapy drug and photothermal agent. Smartly engineered nanocapsules can not only shrink and decompose into small-sized nanodrugs upon drug release but also can regulate the TME to overproduce reactive oxygen species for enhanced synergistic therapy in tumors. In vivo experiments demonstrate that these nanocapsules can target to tumor sites through fluorescence/magnetic resonance imaging and offer remarkable therapeutic results. Our synthetic strategy provides a platform for next generation smart nanocapsules with enhanced permeability and retention effect, multimodal anticancer theranostics, and biodegradability.

Date: 2019
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DOI: 10.1038/s41467-019-12142-4

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