Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache

Caroline Bonnet, Jizhe Hao, Nancy Osorio, Anne Donnet, Virginie Penalba, Jérôme Ruel and Patrick Delmas ()
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Caroline Bonnet: Laboratoire de Neurosciences Cognitives
Jizhe Hao: Laboratoire de Neurosciences Cognitives
Nancy Osorio: Laboratoire de Neurosciences Cognitives
Anne Donnet: Hôpital de la Timone
Virginie Penalba: Laboratoire de Neurosciences Cognitives
Jérôme Ruel: Laboratoire de Neurosciences Cognitives
Patrick Delmas: Laboratoire de Neurosciences Cognitives

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Medication-overuse headaches (MOH) occur with both over-the-counter and pain-relief medicines, including paracetamol, opioids and combination analgesics. The mechanisms that lead to MOH are still uncertain. Here, we show that abnormal activation of Nav1.9 channels by Nitric Oxide (NO) is responsible for MOH induced by triptan migraine medicine. Deletion of the Scn11a gene in MOH mice abrogates NO-mediated symptoms, including cephalic and extracephalic allodynia, photophobia and phonophobia. NO strongly activates Nav1.9 in dural afferent neurons from MOH but not normal mice. Abnormal activation of Nav1.9 triggers CGRP secretion, causing artery dilatation and degranulation of mast cells. In turn, released mast cell mediators potentiates Nav1.9 in meningeal nociceptors, exacerbating inflammation and pain signal. Analysis of signaling networks indicates that PKA is downregulated in trigeminal neurons from MOH mice, relieving its inhibitory action on NO-Nav1.9 coupling. Thus, anomalous activation of Nav1.9 channels by NO, as a result of chronic medication, promotes MOH.

Date: 2019
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DOI: 10.1038/s41467-019-12197-3

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