Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

Xavier Hadoux (), Flora Hui, Jeremiah K. H. Lim, Colin L. Masters, Alice Pébay, Sophie Chevalier, Jason Ha, Samantha Loi, Christopher J. Fowler, Christopher Rowe, Victor L. Villemagne, Edward N. Taylor, Christopher Fluke, Jean-Paul Soucy, Frédéric Lesage, Jean-Philippe Sylvestre, Pedro Rosa-Neto, Sulantha Mathotaarachchi, Serge Gauthier, Ziad S. Nasreddine, Jean Daniel Arbour, Marc-André Rhéaume, Sylvain Beaulieu, Mohamed Dirani, Christine T. O. Nguyen, Bang V. Bui, Robert Williamson, Jonathan G. Crowston and Peter Wijngaarden ()
Additional contact information
Xavier Hadoux: Royal Victorian Eye and Ear Hospital
Flora Hui: Royal Victorian Eye and Ear Hospital
Jeremiah K. H. Lim: University of Melbourne
Colin L. Masters: The University of Melbourne
Alice Pébay: Royal Victorian Eye and Ear Hospital
Sophie Chevalier: Royal Victorian Eye and Ear Hospital
Jason Ha: Royal Victorian Eye and Ear Hospital
Samantha Loi: Neuropsychiatry Unit, North Western Mental Health, Melbourne Health, Royal Melbourne Hospital
Christopher J. Fowler: The University of Melbourne
Christopher Rowe: Austin Health
Victor L. Villemagne: Austin Health
Edward N. Taylor: Swinburne University of Technology
Christopher Fluke: Swinburne University of Technology
Jean-Paul Soucy: McGill University
Frédéric Lesage: Département de Génie électrique
Jean-Philippe Sylvestre: Optina Diagnostics
Pedro Rosa-Neto: McGill University
Sulantha Mathotaarachchi: McGill University
Serge Gauthier: The McGill University Research Centre for Studies in Aging, McGill University
Ziad S. Nasreddine: MoCA Clinic and Institute
Jean Daniel Arbour: Clinique ophtalmologique 2121
Marc-André Rhéaume: Clinique ophtalmologique 2121
Sylvain Beaulieu: Hôpital Maisonneuve-Rosemont
Mohamed Dirani: Royal Victorian Eye and Ear Hospital
Christine T. O. Nguyen: University of Melbourne
Bang V. Bui: University of Melbourne
Robert Williamson: University of Melbourne
Jonathan G. Crowston: Royal Victorian Eye and Ear Hospital
Peter Wijngaarden: Royal Victorian Eye and Ear Hospital

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Studies of rodent models of Alzheimer’s disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of brain Aβ levels. As Aβ has a wavelength-dependent effect on light scatter, we investigate the potential for in vivo retinal hyperspectral imaging to serve as a biomarker of brain Aβ. Significant differences in the retinal reflectance spectra are found between individuals with high Aβ burden on brain PET imaging and mild cognitive impairment (n = 15), and age-matched PET-negative controls (n = 20). Retinal imaging scores are correlated with brain Aβ loads. The findings are validated in an independent cohort, using a second hyperspectral camera. A similar spectral difference is found between control and 5xFAD transgenic mice that accumulate Aβ in the brain and retina. These findings indicate that retinal hyperspectral imaging may predict brain Aβ load.

Date: 2019
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DOI: 10.1038/s41467-019-12242-1

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