Microbe-host interplay in atopic dermatitis and psoriasis

Nanna Fyhrquist, Gareth Muirhead, Stefanie Prast-Nielsen, Marine Jeanmougin, Peter Olah, Tiina Skoog, Gerome Jules-Clement, Micha Feld, Mauricio Barrientos-Somarribas, Hanna Sinkko, Ellen H. Bogaard, Patrick L.J.M. Zeeuwen, Gijs Rikken, Joost Schalkwijk, Hanna Niehues, Walter Däubener, Silvia Kathrin Eller, Helen Alexander, Davide Pennino, Sari Suomela, Ioannis Tessas, Emilia Lybeck, Anna M. Baran, Hamid Darban, Roopesh Singh Gangwar, Ulrich Gerstel, Katharina Jahn, Piia Karisola, Lee Yan, Britta Hansmann, Shintaro Katayama, Stephan Meller, Max Bylesjö, Philippe Hupé, Francesca Levi-Schaffer, Dario Greco, Annamari Ranki, Jens M. Schröder, Jonathan Barker, Juha Kere, Sophia Tsoka, Antti Lauerma, Vassili Soumelis, Frank O. Nestle, Bernhard Homey, Björn Andersson and Harri Alenius ()
Additional contact information
Nanna Fyhrquist: Karolinska Institutet
Gareth Muirhead: King’s College London
Stefanie Prast-Nielsen: Karolinska Institutet
Marine Jeanmougin: Institut Curie
Peter Olah: University Hospital Duesseldorf
Tiina Skoog: Karolinska Institutet
Gerome Jules-Clement: Institut Curie
Micha Feld: University Hospital Duesseldorf
Mauricio Barrientos-Somarribas: Karolinska Institutet
Hanna Sinkko: Karolinska Institutet
Ellen H. Bogaard: Radboud Institute for Molecular Life Sciences
Patrick L.J.M. Zeeuwen: Radboud Institute for Molecular Life Sciences
Gijs Rikken: Radboud Institute for Molecular Life Sciences
Joost Schalkwijk: Radboud Institute for Molecular Life Sciences
Hanna Niehues: Radboud Institute for Molecular Life Sciences
Walter Däubener: Heinrich Heine University Duesseldorf
Silvia Kathrin Eller: Heinrich Heine University Duesseldorf
Helen Alexander: Kings College London
Davide Pennino: King’s College London
Sari Suomela: University of Helsinki and Helsinki University Hospital, Inflammation Centre
Ioannis Tessas: University of Helsinki and Helsinki University Hospital, Inflammation Centre
Emilia Lybeck: University of Helsinki and Helsinki University Hospital, Inflammation Centre
Anna M. Baran: University Hospital Duesseldorf
Hamid Darban: Karolinska Institutet
Roopesh Singh Gangwar: The Hebrew University of Jerusalem
Ulrich Gerstel: University Hospital Schleswig-Holstein
Katharina Jahn: University Hospital Duesseldorf
Piia Karisola: University of Helsinki
Lee Yan: King’s College London
Britta Hansmann: University Hospital Schleswig-Holstein
Shintaro Katayama: Karolinska Institutet
Stephan Meller: University Hospital Duesseldorf
Max Bylesjö: Fios Genomics
Philippe Hupé: Institut Curie
Francesca Levi-Schaffer: The Hebrew University of Jerusalem
Dario Greco: University of Tampere
Annamari Ranki: University of Helsinki and Helsinki University Hospital, Inflammation Centre
Jens M. Schröder: University Hospital Schleswig-Holstein
Jonathan Barker: Kings College London
Juha Kere: Karolinska Institutet
Sophia Tsoka: King’s College London
Antti Lauerma: University of Helsinki and Helsinki University Hospital, Inflammation Centre
Vassili Soumelis: Institut Curie
Frank O. Nestle: King’s College London
Bernhard Homey: University Hospital Duesseldorf
Björn Andersson: Karolinska Institutet
Harri Alenius: Karolinska Institutet

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparative analysis of skin microbial communities coupled to global patterns of cutaneous gene expression in patients with atopic dermatitis or psoriasis. The skin microbiota is analysed by 16S amplicon or whole genome sequencing and the skin transcriptome by microarrays, followed by integration of the data layers. We find that atopic dermatitis and psoriasis can be classified by distinct microbes, which differ from healthy volunteers microbiome composition. Atopic dermatitis is dominated by a single microbe (Staphylococcus aureus), and associated with a disease relevant host transcriptomic signature enriched for skin barrier function, tryptophan metabolism and immune activation. In contrast, psoriasis is characterized by co-occurring communities of microbes with weak associations with disease related gene expression. Our work provides a basis for biomarker discovery and targeted therapies in skin dysbiosis.

Date: 2019
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DOI: 10.1038/s41467-019-12253-y

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