Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter

Mark D. Condon, Nicola J. Platt, Yan-Feng Zhang, Bradley M. Roberts, Michael A. Clements, Stefania Vietti-Michelina, Min-Yee Tseu, Katherine R. Brimblecombe, Sarah Threlfell, Edward O. Mann and Stephanie J. Cragg ()
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Mark D. Condon: Anatomy and Genetics, University of Oxford
Nicola J. Platt: Anatomy and Genetics, University of Oxford
Yan-Feng Zhang: Anatomy and Genetics, University of Oxford
Bradley M. Roberts: Anatomy and Genetics, University of Oxford
Michael A. Clements: Anatomy and Genetics, University of Oxford
Stefania Vietti-Michelina: Anatomy and Genetics, University of Oxford
Min-Yee Tseu: Anatomy and Genetics, University of Oxford
Katherine R. Brimblecombe: Anatomy and Genetics, University of Oxford
Sarah Threlfell: Anatomy and Genetics, University of Oxford
Edward O. Mann: Anatomy and Genetics, University of Oxford
Stephanie J. Cragg: Anatomy and Genetics, University of Oxford

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Mesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing release probability and axonal activity in determining short‐term plasticity of dopamine release, using fast‐scan cyclic voltammetry in the ex vivo mouse striatum. We show that brief short‐term facilitation and longer short term depression are only weakly dependent on the level of initial release, i.e. are release insensitive. Rather, short-term plasticity is strongly determined by mechanisms which govern axonal activation, including K+‐gated excitability and the dopamine transporter, particularly in the dorsal striatum. We identify the dopamine transporter as a master regulator of dopamine short‐term plasticity, governing the balance between release‐dependent and independent mechanisms that also show region‐specific gating.

Date: 2019
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DOI: 10.1038/s41467-019-12264-9

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