Associations of autozygosity with a broad range of human phenotypes

David W Clark, Yukinori Okada, Kristjan H S Moore, Dan Mason, Nicola Pirastu, Ilaria Gandin, Hannele Mattsson, Catriona L K Barnes, Kuang Lin, Jing Hua Zhao, Patrick Deelen, Rebecca Rohde, Claudia Schurmann, Xiuqing Guo, Franco Giulianini, Weihua Zhang, Carolina Medina-Gomez, Robert Karlsson, Yanchun Bao, Traci M Bartz, Clemens Baumbach, Ginevra Biino, Matthew J Bixley, Marco Brumat, Jin-Fang Chai, Tanguy Corre, Diana L Cousminer, Annelot M Dekker, David A Eccles, Kristel R Eijk, Christian Fuchsberger, He Gao, Marine Germain, Scott D Gordon, Hugoline G Haan, Sarah E Harris, Edith Hofer, Alicia Huerta-Chagoya, Catherine Igartua, Iris E Jansen, Yucheng Jia, Tim Kacprowski, Torgny Karlsson, Marcus E Kleber, Shengchao Alfred Li, Ruifang Li-Gao, Anubha Mahajan, Koichi Matsuda, Karina Meidtner, Weihua Meng, May E Montasser, Peter J Most, Matthias Munz, Teresa Nutile, Teemu Palviainen, Gauri Prasad, Rashmi B Prasad, Tallapragada Divya Sri Priyanka, Federica Rizzi, Erika Salvi, Bishwa R Sapkota, Daniel Shriner, Line Skotte, Melissa C Smart, Albert Vernon Smith, Ashley Spek, Cassandra N Spracklen, Rona J Strawbridge, Salman M Tajuddin, Stella Trompet, Constance Turman, Niek Verweij, Clara Viberti, Lihua Wang, Helen R Warren, Robyn E Wootton, Lisa R Yanek, Jie Yao, Noha A Yousri, Wei Zhao, Adebowale A Adeyemo, Saima Afaq, Carlos Alberto Aguilar-Salinas, Masato Akiyama, Matthew L Albert, Matthew A Allison, Maris Alver, Tin Aung, Fereidoun Azizi, Amy R Bentley, Heiner Boeing, Eric Boerwinkle, Judith B Borja, Gert J Borst, Erwin P Bottinger, Linda Broer, Harry Campbell, Stephen Chanock, Miao-Li Chee, Guanjie Chen, Yii- Der I Chen, Zhengming Chen, Yen-Feng Chiu, Massimiliano Cocca, Francis S Collins, Maria Pina Concas, Janie Corley, Giovanni Cugliari, Rob M Dam, Anna Damulina, Maryam S Daneshpour, Felix R Day, Graciela E Delgado, Klodian Dhana, Alexander S F Doney, Marcus Dörr, Ayo P Doumatey, Nduna Dzimiri, S Sunna Ebenesersdóttir, Joshua Elliott, Paul Elliott, Ralf Ewert, Janine F Felix, Krista Fischer, Barry I Freedman, Giorgia Girotto, Anuj Goel, Martin Gögele, Mark O Goodarzi, Mariaelisa Graff, Einat Granot-Hershkovitz, Francine Grodstein, Simonetta Guarrera, Daniel F Gudbjartsson, Kamran Guity, Bjarni Gunnarsson, Yu Guo, Saskia P Hagenaars, Christopher A Haiman, Avner Halevy, Tamara B Harris, Mehdi Hedayati, David A Heel, Makoto Hirata, Imo Höfer, Chao Agnes Hsiung, Jinyan Huang, Yi-Jen Hung, M Arfan Ikram, Anuradha Jagadeesan, Pekka Jousilahti, Yoichiro Kamatani, Masahiro Kanai, Nicola D Kerrison, Thorsten Kessler, Kay-Tee Khaw, Chiea Chuen Khor, Dominique P V Kleijn, Woon-Puay Koh, Ivana Kolcic, Peter Kraft, Bernhard K Krämer, Zoltán Kutalik, Johanna Kuusisto, Claudia Langenberg, Lenore J Launer, Deborah A Lawlor, I-Te Lee, Wen-Jane Lee, Markus M Lerch, Liming Li, Jianjun Liu, Marie Loh, Stephanie J London, Stephanie Loomis, Yingchang Lu, Jian’an Luan, Reedik Mägi, Ani W Manichaikul, Paolo Manunta, Gísli Másson, Nana Matoba, Xue W Mei, Christa Meisinger, Thomas Meitinger, Massimo Mezzavilla, Lili Milani, Iona Y Millwood, Yukihide Momozawa, Amy Moore, Pierre-Emmanuel Morange, Hortensia Moreno-Macías, Trevor A Mori, Alanna C Morrison, Taulant Muka, Yoshinori Murakami, Alison D Murray, Renée Mutsert, Josyf C Mychaleckyj, Mike A Nalls, Matthias Nauck, Matt J Neville, Ilja M Nolte, Ken K Ong, Lorena Orozco, Sandosh Padmanabhan, Gunnar Pálsson, James S Pankow, Cristian Pattaro, Alison Pattie, Ozren Polasek, Neil Poulter, Peter P Pramstaller, Lluis Quintana-Murci, Katri Räikkönen, Sarju Ralhan, Dabeeru C Rao, Wouter Rheenen, Stephen S Rich, Paul M Ridker, Cornelius A Rietveld, Antonietta Robino, Frank J A Rooij, Daniela Ruggiero, Yasaman Saba, Charumathi Sabanayagam, Maria Sabater-Lleal, Cinzia Felicita Sala, Veikko Salomaa, Kevin Sandow, Helena Schmidt, Laura J Scott, William R Scott, Bahareh Sedaghati-Khayat, Bengt Sennblad, Jessica Setten, Peter J Sever, Wayne H-H Sheu, Yuan Shi, Smeeta Shrestha, Sharvari Rahul Shukla, Jon K Sigurdsson, Timo Tonis Sikka, Jai Rup Singh, Blair H Smith, Alena Stančáková, Alice Stanton, John M Starr, Lilja Stefansdottir, Leon Straker, Patrick Sulem, Gardar Sveinbjornsson, Morris A Swertz, Adele M Taylor, Kent D Taylor, Natalie Terzikhan, Yih-Chung Tham, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Annika Tillander, Russell P Tracy, Teresa Tusié-Luna, Ioanna Tzoulaki, Simona Vaccargiu, Jagadish Vangipurapu, Jan H Veldink, Veronique Vitart, Uwe Völker, Eero Vuoksimaa, Salma M Wakil, Melanie Waldenberger, Gurpreet S Wander, Ya Xing Wang, Nicholas J Wareham, Sarah Wild, Chittaranjan S Yajnik, Jian-Min Yuan, Lingyao Zeng, Liang Zhang, Jie Zhou, Najaf Amin, Folkert W Asselbergs, Stephan J L Bakker, Diane M Becker, Benjamin Lehne, David A Bennett, Leonard H Berg, Sonja I Berndt, Dwaipayan Bharadwaj, Lawrence F Bielak, Murielle Bochud, Mike Boehnke, Claude Bouchard, Jonathan P Bradfield, Jennifer A Brody, Archie Campbell, Shai Carmi, Mark J Caulfield, David Cesarini, John C Chambers, Giriraj Ratan Chandak, Ching-Yu Cheng, Marina Ciullo, Marilyn Cornelis, Daniele Cusi, George Davey Smith, Ian J Deary, Rajkumar Dorajoo, Cornelia M Duijn, David Ellinghaus, Jeanette Erdmann, Johan G Eriksson, Evangelos Evangelou, Michele K Evans, Jessica D Faul, Bjarke Feenstra, Mary Feitosa, Sylvain Foisy, Andre Franke, Yechiel Friedlander, Paolo Gasparini, Christian Gieger, Clicerio Gonzalez, Philippe Goyette, Struan F A Grant, Lyn R Griffiths, Leif Groop, Vilmundur Gudnason, Ulf Gyllensten, Hakon Hakonarson, Anders Hamsten, Pim Harst, Chew-Kiat Heng, Andrew A Hicks, Hagit Hochner, Heikki Huikuri, Steven C Hunt, Vincent W V Jaddoe, Philip L Jager, Magnus Johannesson, Åsa Johansson, Jost B Jonas, J Wouter Jukema, Juhani Junttila, Jaakko Kaprio, Sharon L. R. Kardia, Fredrik Karpe, Meena Kumari, Markku Laakso, Sander W Laan, Jari Lahti, Matthias Laudes, Rodney A Lea, Wolfgang Lieb, Thomas Lumley, Nicholas G Martin, Winfried März, Giuseppe Matullo, Mark I McCarthy, Sarah E Medland, Tony R Merriman, Andres Metspalu, Brian F Meyer, Karen L Mohlke, Grant W Montgomery, Dennis Mook-Kanamori, Patricia B Munroe, Kari E North, Dale R Nyholt, Jeffery R O’connell, Carole Ober, Albertine J Oldehinkel, Walter Palmas, Colin Palmer, Gerard G Pasterkamp, Etienne Patin, Craig E Pennell, Louis Perusse, Patricia A Peyser, Mario Pirastu, Tinca J. C. Polderman, David J Porteous, Danielle Posthuma, Bruce M Psaty, John D Rioux, Fernando Rivadeneira, Charles Rotimi, Jerome I Rotter, Igor Rudan, Hester M Ruijter, Dharambir K Sanghera, Naveed Sattar, Reinhold Schmidt, Matthias B Schulze, Heribert Schunkert, Robert A Scott, Alan R Shuldiner, Xueling Sim, Neil Small, Jennifer A Smith, Nona Sotoodehnia, E-Shyong Tai, Alexander Teumer, Nicholas J Timpson, Daniela Toniolo, David-Alexandre Tregouet, Tiinamaija Tuomi, Peter Vollenweider, Carol A Wang, David R Weir, John B Whitfield, Cisca Wijmenga, Tien-Yin Wong, John Wright, Jingyun Yang, Lei Yu, Babette S Zemel, Alan B Zonderman, Markus Perola, Patrik K. E. Magnusson, André G Uitterlinden, Jaspal S Kooner, Daniel I Chasman, Ruth J. F. Loos, Nora Franceschini, Lude Franke, Chris S Haley, Caroline Hayward, Robin G Walters, John R. B. Perry, Tōnu Esko, Agnar Helgason, Kari Stefansson, Peter K Joshi, Michiaki Kubo and James F Wilson ()
Additional contact information
David W Clark: University of Edinburgh
Yukinori Okada: Osaka University Graduate School of Medicine, Suita
Kristjan H S Moore: deCODE genetics/Amgen Inc.
Dan Mason: Bradford Teaching Hospitals NHS Trust
Nicola Pirastu: University of Edinburgh
Ilaria Gandin: Area Science Park
Hannele Mattsson: National Institute for Health and Welfare
Catriona L K Barnes: University of Edinburgh
Kuang Lin: University of Oxford
Jing Hua Zhao: University of Cambridge School of Clinical Medicine
Patrick Deelen: University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen
Rebecca Rohde: University of North Carolina
Claudia Schurmann: Ichan School of Medicine at Mount Sinai
Xiuqing Guo: LABioMed at Harbor-UCLA Medical Center, Torrance
Franco Giulianini: Brigham and Women’s Hospital
Weihua Zhang: Imperial College London
Carolina Medina-Gomez: Erasmus University Medical Center
Robert Karlsson: Karolinska Institutet
Yanchun Bao: Institute for Social and Economic Research, University of Essex
Traci M Bartz: University of Washington
Clemens Baumbach: Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
Ginevra Biino: Institute of Molecular Genetics, National Research Council of Italy
Matthew J Bixley: University of Otago
Marco Brumat: University of Trieste
Jin-Fang Chai: National University of Singapore, Singapore
Tanguy Corre: University of Lausanne
Diana L Cousminer: Children’s Hospital of Philadelphia
Annelot M Dekker: University Medical Centre Utrecht, Utrecht University
David A Eccles: Institute of Health and Biomedical Innovation, Queensland University of Technology
Kristel R Eijk: University Medical Centre Utrecht, Utrecht University
Christian Fuchsberger: Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
He Gao: Imperial College London
Marine Germain: Sorbonne Universités
Scott D Gordon: QIMR Berghofer Institute of Medical Research
Hugoline G Haan: Leiden University Medical Center
Sarah E Harris: University of Edinburgh
Edith Hofer: Medical University of Graz
Alicia Huerta-Chagoya: CONACyT, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Catherine Igartua: University of Chicago
Iris E Jansen: Vrije Universiteit Amsterdam
Yucheng Jia: LABioMed at Harbor-UCLA Medical Center, Torrance
Tim Kacprowski: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Torgny Karlsson: Uppsala University
Marcus E Kleber: Heidelberg University
Shengchao Alfred Li: Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research
Ruifang Li-Gao: Leiden University Medical Center
Anubha Mahajan: University of Oxford
Koichi Matsuda: Graduate school of Frontier Sciences, The University of Tokyo
Karina Meidtner: German Institute of Human Nutrition Potsdam-Rehbruecke
Weihua Meng: Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee
May E Montasser: University of Maryland, School of Medicine
Peter J Most: University of Groningen, University Medical Center Groningen
Matthias Munz: Institute for Cardiogenetics, University of Lübeck
Teresa Nutile: Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR
Teemu Palviainen: Finnish Institute for Molecular Medicine, University of Helsinki
Gauri Prasad: Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology
Rashmi B Prasad: Lund University Diabetes Centre, Lund University, Skåne University Hospital
Tallapragada Divya Sri Priyanka: CSIR-Centre for Cellular and Molecular Biology
Federica Rizzi: ePhood Scientific Unit, ePhood SRL
Erika Salvi: University of Milano
Bishwa R Sapkota: University of Oklahoma Health Sciences Center
Daniel Shriner: National Human Genome Research Institute, National Institutes of Health
Line Skotte: Statens Serum Institut
Melissa C Smart: Institute for Social and Economic Research, University of Essex
Albert Vernon Smith: Icelandic Heart Association
Ashley Spek: Erasmus University Medical Center
Cassandra N Spracklen: University of North Carolina
Rona J Strawbridge: Institute of Health and Wellbeing, University of Glasgow
Salman M Tajuddin: National Institute on Aging, National Institutes of Health
Stella Trompet: Leiden University Medical Center
Constance Turman: Harvard T.H. Chan School of Public Health
Niek Verweij: University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands
Clara Viberti: University of Turin, Italy
Lihua Wang: Washington University School of Medicine
Helen R Warren: Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Robyn E Wootton: MRC Integrative Epidemiology Unit at the University of Bristol
Lisa R Yanek: Johns Hopkins University School of Medicine
Jie Yao: LABioMed at Harbor-UCLA Medical Center, Torrance
Noha A Yousri: Weill Cornell Medicine Qatar
Wei Zhao: University of Michigan
Adebowale A Adeyemo: National Human Genome Research Institute, National Institutes of Health
Saima Afaq: Imperial College London
Carlos Alberto Aguilar-Salinas: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Masato Akiyama: RIKEN Center for Integrative Medical Sciences
Matthew L Albert: Immunobiology of Dendritic Cells, Institut Pasteur
Matthew A Allison: UC San Diego School of Medicine
Maris Alver: University of Tartu, University of Tartu
Tin Aung: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
Fereidoun Azizi: Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
Amy R Bentley: National Human Genome Research Institute, National Institutes of Health
Heiner Boeing: German Institute of Human Nutrition Potsdam-Rehbruecke
Eric Boerwinkle: UTHealth School of Public Health, University of Texas
Judith B Borja: USC-Office of Population Studies Foundation, Inc., Department of Nutrition and Dietetics, Talamban, University of San Carlos
Gert J Borst: University Medical Center Utrecht, University of Utrecht, Utrecht
Erwin P Bottinger: Ichan School of Medicine at Mount Sinai
Linda Broer: Erasmus University Medical Center
Harry Campbell: University of Edinburgh
Stephen Chanock: National Cancer Institute, National Institutes of Health
Miao-Li Chee: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
Guanjie Chen: National Human Genome Research Institute, National Institutes of Health
Yii- Der I Chen: LABioMed at Harbor-UCLA Medical Center, Torrance
Zhengming Chen: University of Oxford
Yen-Feng Chiu: Institute of Population Health Sciences, National Health Research Institutes
Massimiliano Cocca: Institute for Maternal and Child Health - IRCCS Burlo Garofolo
Francis S Collins: National Human Genome Research Institute, National Institutes of Health
Maria Pina Concas: Institute for Maternal and Child Health - IRCCS Burlo Garofolo
Janie Corley: University of Edinburgh
Giovanni Cugliari: University of Turin, Italy
Rob M Dam: National University of Singapore, Singapore
Anna Damulina: Medical University of Graz
Maryam S Daneshpour: Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
Felix R Day: University of Cambridge School of Clinical Medicine
Graciela E Delgado: Heidelberg University
Klodian Dhana: Erasmus University Medical Center
Alexander S F Doney: Molecular and Clinical Medicine, University of Dundee
Marcus Dörr: University Medicine Greifswald
Ayo P Doumatey: National Human Genome Research Institute, National Institutes of Health
Nduna Dzimiri: King Faisal Specialist Hospital and Research Center
S Sunna Ebenesersdóttir: deCODE genetics/Amgen Inc.
Joshua Elliott: Imperial College London
Paul Elliott: Imperial College London
Ralf Ewert: University Medicine Greifswald
Janine F Felix: Erasmus University Medical Center
Krista Fischer: University of Tartu, University of Tartu
Barry I Freedman: Wake Forest School of Medicine
Giorgia Girotto: University of Trieste
Anuj Goel: University of Oxford
Martin Gögele: Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
Mark O Goodarzi: Cedars-Sinai Medical Center
Mariaelisa Graff: University of North Carolina
Einat Granot-Hershkovitz: Hebrew University-Hadassah Medical Center
Francine Grodstein: Harvard T.H. Chan School of Public Health
Simonetta Guarrera: University of Turin, Italy
Daniel F Gudbjartsson: deCODE genetics/Amgen Inc.
Kamran Guity: Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
Bjarni Gunnarsson: deCODE genetics/Amgen Inc.
Yu Guo: Chinese Academy of Medical Sciences
Saskia P Hagenaars: University of Edinburgh
Christopher A Haiman: Keck School of Medicine, University of Southern California
Avner Halevy: Hebrew University-Hadassah Medical Center
Tamara B Harris: National Institute on Aging, National Institutes of Health
Mehdi Hedayati: Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
David A Heel: Blizard Institute, Queen Mary University of London
Makoto Hirata: Institute of Medical Science, The University of Tokyo
Imo Höfer: University Medical Center Utrecht, University of Utrecht, Utrecht
Chao Agnes Hsiung: Institute of Population Health Sciences, National Health Research Institutes
Jinyan Huang: Shanghai Institute of Hematology, State Key Laboratory Of Medical Genomics, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine
Yi-Jen Hung: Tri-Service General Hospital Songshan branch
M Arfan Ikram: Erasmus University Medical Center
Anuradha Jagadeesan: deCODE genetics/Amgen Inc.
Pekka Jousilahti: National Institute for Health and Welfare
Yoichiro Kamatani: RIKEN Center for Integrative Medical Sciences
Masahiro Kanai: Osaka University Graduate School of Medicine, Suita
Nicola D Kerrison: University of Cambridge School of Clinical Medicine
Thorsten Kessler: Klinik für Herz- und Kreislauferkrankungen, Technische Universität München
Kay-Tee Khaw: University of Cambridge
Chiea Chuen Khor: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
Dominique P V Kleijn: University Medical Center Utrecht, University of Utrecht, Utrecht
Woon-Puay Koh: National University of Singapore, Singapore
Ivana Kolcic: University of Split
Peter Kraft: Harvard T.H. Chan School of Public Health
Bernhard K Krämer: Heidelberg University
Zoltán Kutalik: University of Lausanne
Johanna Kuusisto: Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
Claudia Langenberg: University of Cambridge School of Clinical Medicine
Lenore J Launer: National Institute on Aging, National Institutes of Health
Deborah A Lawlor: MRC Integrative Epidemiology Unit at the University of Bristol
I-Te Lee: Taichung Veterans General Hospital
Wen-Jane Lee: Taichung Veterans General Hospital
Markus M Lerch: University Medicine Greifswald
Liming Li: Peking University Health Science Centre, Peking University
Jianjun Liu: Yong Loo Lin School of Medicine, National University of Singapore
Marie Loh: Imperial College London
Stephanie J London: National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services
Stephanie Loomis: Johns Hopkins Bloomberg School of Public Health
Yingchang Lu: Ichan School of Medicine at Mount Sinai
Jian’an Luan: University of Cambridge School of Clinical Medicine
Reedik Mägi: University of Tartu, University of Tartu
Ani W Manichaikul: University of Virginia School of Medicine
Paolo Manunta: IRCCS San Raffaele Scientific Institute, Università Vita Salute San Raffaele
Gísli Másson: deCODE genetics/Amgen Inc.
Nana Matoba: RIKEN Center for Integrative Medical Sciences
Xue W Mei: University of Oxford
Christa Meisinger: Independent Research Group Clinical Epidemiology
Thomas Meitinger: Institute of Human Genetics, Helmholtz Zentrum Muenchen
Massimo Mezzavilla: Institute for Maternal and Child Health - IRCCS Burlo Garofolo
Lili Milani: Institute of Genomics, University of Tartu
Iona Y Millwood: University of Oxford
Yukihide Momozawa: RIKEN Center for Integrative Medical Sciences
Amy Moore: National Cancer Institute, National Institutes of Health
Pierre-Emmanuel Morange: Laboratory of Haematology, La Timone Hospital
Hortensia Moreno-Macías: Universidad Autónoma Metropolitana
Trevor A Mori: The University of Western Australia
Alanna C Morrison: The University of Texas Health Science Center at Houston, School of Public Health, Department of Epidemiology, Human Genetics and Environmental Sciences
Taulant Muka: Erasmus University Medical Center
Yoshinori Murakami: Institute of Medical Science, The University of Tokyo
Alison D Murray: The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen
Renée Mutsert: Leiden University Medical Center
Josyf C Mychaleckyj: University of Virginia School of Medicine
Mike A Nalls: Laboratory of Neurogenetics
Matthias Nauck: partner site Greifswald
Matt J Neville: University of Oxford, Headington
Ilja M Nolte: University of Groningen, University Medical Center Groningen
Ken K Ong: University of Cambridge School of Clinical Medicine
Lorena Orozco: Instituto Nacional de Medicina Genómica
Sandosh Padmanabhan: Institute of Cardiovascular and Medical Sciences, University of Glasgow
Gunnar Pálsson: deCODE genetics/Amgen Inc.
James S Pankow: School of Public Health, University of Minnesota
Cristian Pattaro: Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
Alison Pattie: University of Edinburgh
Ozren Polasek: University of Split
Neil Poulter: International Centre for Circulatory Health, Imperial College London
Peter P Pramstaller: Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
Lluis Quintana-Murci: Human Evolutionary Genetics Unit, Institut Pasteur
Katri Räikkönen: University of Helsinki, University of Helsinki
Sarju Ralhan: Hero Heart Institute and Dyanand Medical College and Hospital
Dabeeru C Rao: Washington University School of Medicine
Wouter Rheenen: University Medical Centre Utrecht, Utrecht University
Stephen S Rich: University of Virginia School of Medicine
Paul M Ridker: Brigham and Women’s Hospital
Cornelius A Rietveld: Erasmus School of Economics, Erasmus University Rotterdam
Antonietta Robino: Institute for Maternal and Child Health - IRCCS Burlo Garofolo
Frank J A Rooij: Erasmus University Medical Center
Daniela Ruggiero: Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR
Yasaman Saba: Medical University of Graz
Charumathi Sabanayagam: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
Maria Sabater-Lleal: Karolinska Institutet
Cinzia Felicita Sala: San Raffaele Research Institute
Veikko Salomaa: National Institute for Health and Welfare
Kevin Sandow: LABioMed at Harbor-UCLA Medical Center, Torrance
Helena Schmidt: Medical University of Graz
Laura J Scott: University of Michigan
William R Scott: Imperial College London
Bahareh Sedaghati-Khayat: Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
Bengt Sennblad: Karolinska Institutet
Jessica Setten: University Medical Center Utrecht, University of Utrecht, Utrecht
Peter J Sever: International Centre for Circulatory Health, Imperial College London
Wayne H-H Sheu: National Defense Medical Center
Yuan Shi: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
Smeeta Shrestha: CSIR-Centre for Cellular and Molecular Biology
Sharvari Rahul Shukla: Diabetes Unit, KEM Hospital and Research Centre
Jon K Sigurdsson: deCODE genetics/Amgen Inc.
Timo Tonis Sikka: University of Tartu, University of Tartu
Jai Rup Singh: Panjab University
Blair H Smith: Ninewells Hospital and Medical School, University of Dundee
Alena Stančáková: Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
Alice Stanton: RCSI Molecular & Cellular Therapeutics (MCT), Royal College of Surgeons in Ireland, RCSI Education & Research Centre, Beaumont Hospital
John M Starr: University of Edinburgh
Lilja Stefansdottir: deCODE genetics/Amgen Inc.
Leon Straker: School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University
Patrick Sulem: deCODE genetics/Amgen Inc.
Gardar Sveinbjornsson: deCODE genetics/Amgen Inc.
Morris A Swertz: University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen
Adele M Taylor: University of Edinburgh
Kent D Taylor: LABioMed at Harbor-UCLA Medical Center, Torrance
Natalie Terzikhan: Erasmus University Medical Center
Yih-Chung Tham: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
Gudmar Thorleifsson: deCODE genetics/Amgen Inc.
Unnur Thorsteinsdottir: deCODE genetics/Amgen Inc.
Annika Tillander: Karolinska Institutet
Russell P Tracy: University of Vermont
Teresa Tusié-Luna: Instituto de Investigaciones Biomédicas, UNAM
Ioanna Tzoulaki: Imperial College London
Simona Vaccargiu: Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy
Jagadish Vangipurapu: Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
Jan H Veldink: University Medical Centre Utrecht, Utrecht University
Veronique Vitart: Institute of Genetics and Molecular Medicine, University of Edinburgh
Uwe Völker: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Eero Vuoksimaa: Institute for Molecular Medicine Finland (FIMM), University of Helsinki
Salma M Wakil: King Faisal Specialist Hospital and Research Center
Melanie Waldenberger: Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
Gurpreet S Wander: Hero DMC Heart Institute, Dayanand Medical College & Hospital
Ya Xing Wang: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab
Nicholas J Wareham: University of Cambridge School of Clinical Medicine
Sarah Wild: Usher Institute of Population Health and Informatics, University of Edinburgh
Chittaranjan S Yajnik: Diabetes Unit, K.E.M. Hospital Research Centre
Jian-Min Yuan: Graduate School of Public Health, University of Pittsburgh
Lingyao Zeng: Klinik für Herz- und Kreislauferkrankungen, Technische Universität München
Liang Zhang: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
Jie Zhou: National Human Genome Research Institute, National Institutes of Health
Najaf Amin: Erasmus University Medical Center
Folkert W Asselbergs: University Medical Center Utrecht, University of Utrecht, Utrecht
Stephan J L Bakker: University Medical Center Groningen, University of Groningen
Diane M Becker: Johns Hopkins University School of Medicine
Benjamin Lehne: Imperial College London
David A Bennett: Rush University Medical Center
Leonard H Berg: University Medical Centre Utrecht, Utrecht University
Sonja I Berndt: National Cancer Institute, National Institutes of Health
Dwaipayan Bharadwaj: School of Biotechnology, Jawaharlal Nehru University
Lawrence F Bielak: University of Michigan
Murielle Bochud: University of Lausanne
Mike Boehnke: University of Michigan
Claude Bouchard: Pennington Biomedical Research Center
Jonathan P Bradfield: Children’s Hospital of Philadelphia
Jennifer A Brody: University of Washington
Archie Campbell: Institute of Genetics & Molecular Medicine, University of Edinburgh
Shai Carmi: Hebrew University-Hadassah Medical Center
Mark J Caulfield: Barts and The London School of Medicine and Dentistry, Queen Mary University of London
John C Chambers: Imperial College London
Giriraj Ratan Chandak: CSIR-Centre for Cellular and Molecular Biology
Ching-Yu Cheng: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
Marina Ciullo: Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR
Marilyn Cornelis: Northwestern University Feinberg School of Medicine
Daniele Cusi: University of Milano
George Davey Smith: MRC Integrative Epidemiology Unit at the University of Bristol
Ian J Deary: University of Edinburgh
Rajkumar Dorajoo: Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore
Cornelia M Duijn: University of Oxford
David Ellinghaus: Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
Jeanette Erdmann: Institute for Cardiogenetics, University of Lübeck
Johan G Eriksson: University of Helsinki
Evangelos Evangelou: Imperial College London
Michele K Evans: National Institute on Aging, National Institutes of Health
Jessica D Faul: Institute for Social Research, University of Michigan
Bjarke Feenstra: Statens Serum Institut
Mary Feitosa: Washington University School of Medicine
Sylvain Foisy: Montreal Heart Institute
Andre Franke: Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
Yechiel Friedlander: Hebrew University-Hadassah Medical Center
Paolo Gasparini: University of Trieste
Christian Gieger: Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
Clicerio Gonzalez: Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica
Philippe Goyette: Montreal Heart Institute
Struan F A Grant: University of Pennsylvania
Lyn R Griffiths: Institute of Health and Biomedical Innovation, Queensland University of Technology
Leif Groop: Finnish Institute for Molecular Medicine, University of Helsinki
Vilmundur Gudnason: Icelandic Heart Association
Ulf Gyllensten: Uppsala University
Hakon Hakonarson: Children’s Hospital of Philadelphia
Anders Hamsten: Centre for Molecular Medicine
Pim Harst: University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands
Chew-Kiat Heng: Yong Loo Lin School of Medicine, National University of Singapore
Andrew A Hicks: Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
Hagit Hochner: Hebrew University-Hadassah Medical Center
Heikki Huikuri: Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital
Steven C Hunt: Weill Cornell Medicine Qatar
Vincent W V Jaddoe: Erasmus University Medical Center
Philip L Jager: Columbia University Medical Center
Åsa Johansson: Uppsala University
Jost B Jonas: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab
J Wouter Jukema: Leiden University Medical Center
Juhani Junttila: Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital
Jaakko Kaprio: Finnish Institute for Molecular Medicine, University of Helsinki
Sharon L. R. Kardia: University of Michigan
Fredrik Karpe: University of Oxford, Headington
Meena Kumari: Institute for Social and Economic Research, University of Essex
Markku Laakso: Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
Sander W Laan: University Medical Center Utrecht, University of Utrecht
Jari Lahti: University of Helsinki, University of Helsinki
Matthias Laudes: University Hospital Schleswig-Holstein (UKSH)
Rodney A Lea: Institute of Health and Biomedical Innovation, Queensland University of Technology
Wolfgang Lieb: Institute of Epidemiology and PopGen Biobank, University of Kiel
Thomas Lumley: University of Auckland
Nicholas G Martin: QIMR Berghofer Institute of Medical Research
Winfried März: Heidelberg University
Giuseppe Matullo: University of Turin, Italy
Mark I McCarthy: University of Oxford
Sarah E Medland: QIMR Berghofer Institute of Medical Research
Tony R Merriman: University of Otago
Andres Metspalu: University of Tartu, University of Tartu
Brian F Meyer: King Faisal Specialist Hospital and Research Centre
Karen L Mohlke: University of North Carolina
Grant W Montgomery: QIMR Berghofer Institute of Medical Research
Dennis Mook-Kanamori: Leiden University Medical Center
Patricia B Munroe: Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Kari E North: University of North Carolina
Dale R Nyholt: QIMR Berghofer Institute of Medical Research
Jeffery R O’connell: University of Maryland, School of Medicine
Carole Ober: University of Chicago
Albertine J Oldehinkel: Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen
Walter Palmas: Columbia University Medical Center
Colin Palmer: Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, The School of Medicine, University of Dundee
Gerard G Pasterkamp: University Medical Center Utrecht, University of Utrecht, Utrecht
Etienne Patin: Human Evolutionary Genetics Unit, Institut Pasteur
Craig E Pennell: School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle
Louis Perusse: Laval University
Patricia A Peyser: University of Michigan
Mario Pirastu: Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy
Tinca J. C. Polderman: Vrije Universiteit Amsterdam
David J Porteous: University of Edinburgh
Danielle Posthuma: Vrije Universiteit Amsterdam
Bruce M Psaty: University of Washington
John D Rioux: Montreal Heart Institute
Fernando Rivadeneira: Erasmus University Medical Center
Charles Rotimi: National Human Genome Research Institute, National Institutes of Health
Jerome I Rotter: LABioMed at Harbor-UCLA Medical Center, Torrance
Igor Rudan: University of Edinburgh
Hester M Ruijter: University Medical Center Utrecht, University of Utrecht, Utrecht
Dharambir K Sanghera: University of Oklahoma Health Sciences Center
Naveed Sattar: Institute of Cardiovascular and Medical Sciences, University of Glasgow
Reinhold Schmidt: Medical University of Graz
Matthias B Schulze: German Institute of Human Nutrition Potsdam-Rehbruecke
Heribert Schunkert: Klinik für Herz- und Kreislauferkrankungen, Technische Universität München
Robert A Scott: University of Cambridge School of Clinical Medicine
Alan R Shuldiner: University of Maryland, School of Medicine
Xueling Sim: National University of Singapore, Singapore
Neil Small: University of Bradford
Jennifer A Smith: University of Michigan
Nona Sotoodehnia: University of Washington
E-Shyong Tai: National University of Singapore, Singapore
Alexander Teumer: partner site Greifswald
Nicholas J Timpson: MRC Integrative Epidemiology Unit at the University of Bristol
Daniela Toniolo: San Raffaele Research Institute
David-Alexandre Tregouet: Sorbonne Universités
Tiinamaija Tuomi: University of Helsinki
Peter Vollenweider: Lausanne University Hospital
Carol A Wang: School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle
David R Weir: Institute for Social Research, University of Michigan
John B Whitfield: QIMR Berghofer Institute of Medical Research
Cisca Wijmenga: University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen
Tien-Yin Wong: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
John Wright: Bradford Teaching Hospitals NHS Trust
Jingyun Yang: Rush University Medical Center
Lei Yu: Rush University Medical Center
Babette S Zemel: Perelman School of Medicine, University of Pennsylvania
Alan B Zonderman: National Institute on Aging, National Institutes of Health
Markus Perola: National Institute for Health and Welfare
Patrik K. E. Magnusson: Karolinska Institutet
André G Uitterlinden: Erasmus University Medical Center
Jaspal S Kooner: Ealing Hospital, Middlesex
Daniel I Chasman: Brigham and Women’s Hospital
Ruth J. F. Loos: Ichan School of Medicine at Mount Sinai
Nora Franceschini: University of North Carolina
Lude Franke: University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen
Chris S Haley: Institute of Genetics and Molecular Medicine, University of Edinburgh
Caroline Hayward: Institute of Genetics and Molecular Medicine, University of Edinburgh
Robin G Walters: University of Oxford
John R. B. Perry: University of Cambridge School of Clinical Medicine
Tōnu Esko: University of Tartu, University of Tartu
Agnar Helgason: deCODE genetics/Amgen Inc.
Kari Stefansson: deCODE genetics/Amgen Inc.
Peter K Joshi: University of Edinburgh
Michiaki Kubo: RIKEN Center for Integrative Medical Sciences
James F Wilson: University of Edinburgh

Nature Communications, 2019, vol. 10, issue 1, 1-17

Abstract: Abstract In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p

Date: 2019
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DOI: 10.1038/s41467-019-12283-6

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