Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Erick X. Pérez-Guzmán, Petraleigh Pantoja, Crisanta Serrano-Collazo, Mariah A. Hassert, Alexandra Ortiz-Rosa, Idia V. Rodríguez, Luis Giavedoni, Vida Hodara, Laura Parodi, Lorna Cruz, Teresa Arana, Laura J. White, Melween I. Martínez, Daniela Weiskopf, James D. Brien, Aravinda Silva, Amelia K. Pinto and Carlos A. Sariol ()
Additional contact information
Erick X. Pérez-Guzmán: University of Puerto Rico-Medical Sciences Campus
Petraleigh Pantoja: University of Puerto Rico-Medical Sciences Campus
Crisanta Serrano-Collazo: University of Puerto Rico-Medical Sciences Campus
Mariah A. Hassert: Saint Louis University School of Medicine
Alexandra Ortiz-Rosa: University of Puerto Rico-Río Piedras Campus
Idia V. Rodríguez: University of Puerto Rico-Medical Sciences Campus
Luis Giavedoni: Texas Biomedical Research Institute
Vida Hodara: Texas Biomedical Research Institute
Laura Parodi: Texas Biomedical Research Institute
Lorna Cruz: University of Puerto Rico-Medical Sciences Campus
Teresa Arana: University of Puerto Rico-Medical Sciences Campus
Laura J. White: University of North Carolina-Chapel Hill
Melween I. Martínez: University of Puerto Rico-Medical Sciences Campus
Daniela Weiskopf: La Jolla Institute for Immunology
James D. Brien: Saint Louis University School of Medicine
Aravinda Silva: University of North Carolina-Chapel Hill
Amelia K. Pinto: Saint Louis University School of Medicine
Carlos A. Sariol: University of Puerto Rico-Medical Sciences Campus

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.

Date: 2019
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DOI: 10.1038/s41467-019-12295-2

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