Surface-kinetics mediated mesoporous multipods for enhanced bacterial adhesion and inhibition

Tiancong Zhao, Liang Chen, Peiyuan Wang, Benhao Li, Runfeng Lin, Areej Abdulkareem Al-Khalaf, Wael N. Hozzein, Fan Zhang, Xiaomin Li () and Dongyuan Zhao ()
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Tiancong Zhao: Fudan University
Liang Chen: Fudan University
Peiyuan Wang: Fudan University
Benhao Li: Fudan University
Runfeng Lin: Fudan University
Areej Abdulkareem Al-Khalaf: Princess Nourah Bint Abdulrahman University
Wael N. Hozzein: King Saud University
Fan Zhang: Fudan University
Xiaomin Li: Fudan University
Dongyuan Zhao: Fudan University

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Despite the importance of nanoparticle’s multipods topology in multivalent-interactions enhanced nano-bio interactions, the precise manipulation of multipods surface topological structures is still a great challenge. Herein, the surface-kinetics mediated multi-site nucleation strategy is demonstrated for the fabrication of mesoporous multipods with precisely tunable surface topological structures. Tribulus-like tetra-pods Fe3O4@SiO2@RF&PMOs (RF = resorcinol-formaldehyde resin, PMO = periodic mesoporous organosilica) nanocomposites have successfully been fabricated with a centering core@shell Fe3O4@SiO2@RF nanoparticle, and four surrounding PMO nanocubes as pods. By manipulating the number of nucleation sites through mediating surface kinetics, a series of multipods mesoporous nanocomposites with precisely controllable surface topological structures are formed, including Janus with only one pod, nearly plane distributed dual-pods and tri-pods, three-dimensional tetrahedral structured tetra-pods, etc. The multipods topology endows the mesoporous nanocomposites enhanced bacteria adhesion ability. Particularly, the tribulus-like tetra-pods mesoporous nanoparticles show ~100% bacteria segregation and long-term inhibition over 90% after antibiotic loading.

Date: 2019
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DOI: 10.1038/s41467-019-12378-0

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