Distinct transcriptional roles for Histone H3-K56 acetylation during the cell cycle in Yeast

Salih Topal, Pauline Vasseur, Marta Radman-Livaja and Craig L. Peterson ()
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Salih Topal: University of Massachusetts Medical School
Pauline Vasseur: Institut de Génétique Moléculaire de Montpellier
Marta Radman-Livaja: Institut de Génétique Moléculaire de Montpellier
Craig L. Peterson: University of Massachusetts Medical School

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Dynamic disruption and reassembly of promoter-proximal nucleosomes is a conserved hallmark of transcriptionally active chromatin. Histone H3-K56 acetylation (H3K56Ac) enhances these turnover events and promotes nucleosome assembly during S phase. Here we sequence nascent transcripts to investigate the impact of H3K56Ac on transcription throughout the yeast cell cycle. We find that H3K56Ac is a genome-wide activator of transcription. While H3K56Ac has a major impact on transcription initiation, it also appears to promote elongation and/or termination. In contrast, H3K56Ac represses promiscuous transcription that occurs immediately following replication fork passage, in this case by promoting efficient nucleosome assembly. We also detect a stepwise increase in transcription as cells transit S phase and enter G2, but this response to increased gene dosage does not require H3K56Ac. Thus, a single histone mark can exert both positive and negative impacts on transcription that are coupled to different cell cycle events.

Date: 2019
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DOI: 10.1038/s41467-019-12400-5

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