CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

Yuhong Chen, Mei Yu, Yongwei Zheng, Guoping Fu, Gang Xin, Wen Zhu, Lan Luo, Robert Burns, Quan-Zhen Li, Alexander L. Dent, Nan Zhu, Weiguo Cui, Laurent Malherbe, Renren Wen and Demin Wang ()
Additional contact information
Yuhong Chen: Blood Research Institute, Versiti
Mei Yu: Blood Research Institute, Versiti
Yongwei Zheng: Blood Research Institute, Versiti
Guoping Fu: Blood Research Institute, Versiti
Gang Xin: Blood Research Institute, Versiti
Wen Zhu: Blood Research Institute, Versiti
Lan Luo: Blood Research Institute, Versiti
Robert Burns: Blood Research Institute, Versiti
Quan-Zhen Li: University of Texas Southwestern Medical Center
Alexander L. Dent: Indiana University School of Medicine
Nan Zhu: Blood Research Institute, Versiti
Weiguo Cui: Blood Research Institute, Versiti
Laurent Malherbe: Toxicology Division, Eli Lilly
Renren Wen: Blood Research Institute, Versiti
Demin Wang: Blood Research Institute, Versiti

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Many autoimmune diseases are characterized by the production of autoantibodies. The current view is that CD4+ T follicular helper (Tfh) cells are the main subset regulating autoreactive B cells. Here we report a CXCR5+PD1+ Tfh subset of CD8+ T cells whose development and function are negatively modulated by Stat5. These CD8+ Tfh cells regulate the germinal center B cell response and control autoantibody production, as deficiency of Stat5 in CD8 T cells leads to an increase of CD8+ Tfh cells, resulting in the breakdown of B cell tolerance and concomitant autoantibody production. CD8+ Tfh cells share similar gene signatures with CD4+ Tfh, and require CD40L/CD40 and TCR/MHCI interactions to deliver help to B cells. Our study thus highlights the diversity of follicular T cell subsets that contribute to the breakdown of B-cell tolerance.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-12446-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12446-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-12446-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().