Anatomy and function of the vertebral column lymphatic network in mice

Laurent Jacob, Ligia Simoes Braga Boisserand, Luiz Henrique Medeiros Geraldo, Jose Brito Neto, Thomas Mathivet, Salli Antila, Besma Barka, Yunling Xu, Jean-Mickael Thomas, Juliette Pestel, Marie-Stéphane Aigrot, Eric Song, Harri Nurmi, Seyoung Lee, Kari Alitalo, Nicolas Renier, Anne Eichmann and Jean-Leon Thomas ()
Additional contact information
Laurent Jacob: Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
Ligia Simoes Braga Boisserand: Yale University School of Medicine
Luiz Henrique Medeiros Geraldo: INSERM U970, Paris Cardiovascular Research Center
Jose Brito Neto: Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
Thomas Mathivet: INSERM U970, Paris Cardiovascular Research Center
Salli Antila: University of Helsinki
Besma Barka: Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
Yunling Xu: INSERM U970, Paris Cardiovascular Research Center
Jean-Mickael Thomas: Ecole Nationale Supérieure d’Art de la Villa Arson
Juliette Pestel: Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
Marie-Stéphane Aigrot: Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
Eric Song: Yale University School of Medicine
Harri Nurmi: University of Helsinki
Seyoung Lee: Yale University School of Medicine
Kari Alitalo: University of Helsinki
Nicolas Renier: Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière
Anne Eichmann: INSERM U970, Paris Cardiovascular Research Center
Jean-Leon Thomas: Université Pierre et Marie Curie Paris 06 UMRS1127, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière

Nature Communications, 2019, vol. 10, issue 1, 1-16

Abstract: Abstract Cranial lymphatic vessels (LVs) are involved in the transport of fluids, macromolecules and central nervous system (CNS) immune responses. Little information about spinal LVs is available, because these delicate structures are embedded within vertebral tissues and difficult to visualize using traditional histology. Here we show an extended vertebral column LV network using three-dimensional imaging of decalcified iDISCO+-clarified spine segments. Vertebral LVs connect to peripheral sensory and sympathetic ganglia and form metameric vertebral circuits connecting to lymph nodes and the thoracic duct. They drain the epidural space and the dura mater around the spinal cord and associate with leukocytes. Vertebral LVs remodel extensively after spinal cord injury and VEGF-C-induced vertebral lymphangiogenesis exacerbates the inflammatory responses, T cell infiltration and demyelination following focal spinal cord lesion. Therefore, vertebral LVs add to skull meningeal LVs as gatekeepers of CNS immunity and may be potential targets to improve the maintenance and repair of spinal tissues.

Date: 2019
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DOI: 10.1038/s41467-019-12568-w

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