Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water

Julia Y. Rho, Henry Cox, Edward D. H. Mansfield, Sean H. Ellacott, Raoul Peltier, Johannes C. Brendel, Matthias Hartlieb, Thomas A. Waigh and Sébastien Perrier ()
Additional contact information
Julia Y. Rho: University of Warwick
Henry Cox: University of Manchester
Edward D. H. Mansfield: University of Warwick
Sean H. Ellacott: University of Warwick
Raoul Peltier: University of Warwick
Johannes C. Brendel: University of Warwick
Matthias Hartlieb: University of Warwick
Thomas A. Waigh: University of Manchester
Sébastien Perrier: University of Warwick

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract Self-assembling peptides have the ability to spontaneously aggregate into large ordered structures. The reversibility of the peptide hydrogen bonded supramolecular assembly make them tunable to a host of different applications, although it leaves them highly dynamic and prone to disassembly at the low concentration needed for biological applications. Here we demonstrate that a secondary hydrophobic interaction, near the peptide core, can stabilise the highly dynamic peptide bonds, without losing the vital solubility of the systems in aqueous conditions. This hierarchical self-assembly process can be used to stabilise a range of different β-sheet hydrogen bonded architectures.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-12586-8 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12586-8

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-12586-8

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().