Mice with hyper-long telomeres show less metabolic aging and longer lifespans

Miguel A. Muñoz-Lorente, Alba C. Cano-Martin and Maria A. Blasco ()
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Miguel A. Muñoz-Lorente: Spanish National Cancer Centre (CNIO)
Alba C. Cano-Martin: Spanish National Cancer Centre (CNIO)
Maria A. Blasco: Spanish National Cancer Centre (CNIO)

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal (hyper-long telomeres) in the absence of genetic manipulations, which contributed to all mouse tissues. To address whether hyper-long telomeres have deleterious effects, we generated mice in which 100% of their cells are derived from hyper-long telomere ES cells. We observe that these mice have longer telomeres and less DNA damage with aging. Hyper-long telomere mice are lean and show low cholesterol and LDL levels, as well as improved glucose and insulin tolerance. Hyper-long telomere mice also have less incidence of cancer and an increased longevity. These findings demonstrate that longer telomeres than normal in a given species are not deleterious but instead, show beneficial effects.

Date: 2019
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DOI: 10.1038/s41467-019-12664-x

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