Topology, landscapes, and biomolecular energy transport

Justin E. Elenewski, Kirill A. Velizhanin and Michael Zwolak ()
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Justin E. Elenewski: National Institute of Standards and Technology
Kirill A. Velizhanin: Los Alamos National Laboratory
Michael Zwolak: National Institute of Standards and Technology

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract While ubiquitous, energy redistribution remains a poorly understood facet of the nonequilibrium thermodynamics of biomolecules. At the molecular level, finite-size effects, pronounced nonlinearities, and ballistic processes produce behavior that diverges from the macroscale. Here, we show that transient thermal transport reflects macromolecular energy landscape architecture through the topological characteristics of molecular contacts and the nonlinear processes that mediate dynamics. While the former determines transport pathways via pairwise interactions, the latter reflects frustration within the landscape for local conformational rearrangements. Unlike transport through small-molecule systems, such as alkanes, nonlinearity dominates over coherent processes at even quite short time- and length-scales. Our exhaustive all-atom simulations and novel local-in-time and space analysis, applicable to both theory and experiment, permit dissection of energy migration in biomolecules. The approach demonstrates that vibrational energy transport can probe otherwise inaccessible aspects of macromolecular dynamics and interactions that underly biological function.

Date: 2019
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DOI: 10.1038/s41467-019-12700-w

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