Large scale and integrated platform for digital mass culture of anchorage dependent cells

Kyoung Won Cho, Seok Joo Kim, Jaemin Kim, Seuk Young Song, Wang Hee Lee, Liu Wang, Min Soh, Nanshu Lu, Taeghwan Hyeon, Byung-Soo Kim () and Dae-Hyeong Kim ()
Additional contact information
Kyoung Won Cho: Institute for Basic Science (IBS)
Seok Joo Kim: Institute for Basic Science (IBS)
Jaemin Kim: Institute for Basic Science (IBS)
Seuk Young Song: Seoul National University
Wang Hee Lee: Institute for Basic Science (IBS)
Liu Wang: Texas Materials Institute, University of Texas at Austin
Min Soh: Institute for Basic Science (IBS)
Nanshu Lu: Texas Materials Institute, University of Texas at Austin
Taeghwan Hyeon: Institute for Basic Science (IBS)
Byung-Soo Kim: Seoul National University
Dae-Hyeong Kim: Institute for Basic Science (IBS)

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Industrial applications of anchorage-dependent cells require large-scale cell culture with multifunctional monitoring of culture conditions and control of cell behaviour. Here, we introduce a large-scale, integrated, and smart cell-culture platform (LISCCP) that facilitates digital mass culture of anchorage-dependent cells. LISCCP is devised through large-scale integration of ultrathin sensors and stimulator arrays in multiple layers. LISCCP provides real-time, 3D, and multimodal monitoring and localized control of the cultured cells, which thereby allows minimizing operation labour and maximizing cell culture performance. Wireless integration of multiple LISCCPs across multiple incubators further amplifies the culture scale and enables digital monitoring and local control of numerous culture layers, making the large-scale culture more efficient. Thus, LISCCP can transform conventional labour-intensive and high-cost cell cultures into efficient digital mass cell cultures. This platform could be useful for industrial applications of cell cultures such as in vitro toxicity testing of drugs and cosmetics and clinical scale production of cells for cell therapy.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-12777-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12777-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-12777-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().