Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS

Minou Djannatian, Sebastian Timmler, Martina Arends, Manja Luckner, Marie-Theres Weil, Ioannis Alexopoulos, Nicolas Snaidero, Bettina Schmid, Thomas Misgeld, Wiebke Möbius, Martina Schifferer, Elior Peles and Mikael Simons ()
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Minou Djannatian: Technical University Munich
Sebastian Timmler: Technical University Munich
Martina Arends: Technical University Munich
Manja Luckner: Technical University Munich
Marie-Theres Weil: Max Planck Institute of Experimental Medicine
Ioannis Alexopoulos: Technical University Munich
Nicolas Snaidero: Technical University Munich
Bettina Schmid: German Center for Neurodegenerative Diseases (DZNE)
Thomas Misgeld: Technical University Munich
Wiebke Möbius: Max Planck Institute of Experimental Medicine
Martina Schifferer: Technical University Munich
Elior Peles: The Weizmann Institute of Science
Mikael Simons: Technical University Munich

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Central nervous system myelin is a multilayered membrane produced by oligodendrocytes to increase neural processing speed and efficiency, but the molecular mechanisms underlying axonal selection and myelin wrapping are unknown. Here, using combined morphological and molecular analyses in mice and zebrafish, we show that adhesion molecules of the paranodal and the internodal segment work synergistically using overlapping functions to regulate axonal interaction and myelin wrapping. In the absence of these adhesive systems, axonal recognition by myelin is impaired with myelin growing on top of previously myelinated fibers, around neuronal cell bodies and above nodes of Ranvier. In addition, myelin wrapping is disturbed with the leading edge moving away from the axon and in between previously formed layers. These data show how two adhesive systems function together to guide axonal ensheathment and myelin wrapping, and provide a mechanistic understanding of how the spatial organization of myelin is achieved.

Date: 2019
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DOI: 10.1038/s41467-019-12789-z

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