Cortical astrocytes develop in a plastic manner at both clonal and cellular levels

Solène Clavreul, Lamiae Abdeladim, Edwin Hernández-Garzón, Dragos Niculescu, Jason Durand, Sio-Hoï Ieng, Raphaëlle Barry, Gilles Bonvento, Emmanuel Beaurepaire, Jean Livet () and Karine Loulier ()
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Solène Clavreul: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Lamiae Abdeladim: Ecole polytechnique, CNRS, INSERM, IP Paris
Edwin Hernández-Garzón: CNRS UMR 9199, Université Paris-Sud, Université Paris-Saclay
Dragos Niculescu: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Jason Durand: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Sio-Hoï Ieng: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Raphaëlle Barry: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Gilles Bonvento: CNRS UMR 9199, Université Paris-Sud, Université Paris-Saclay
Emmanuel Beaurepaire: Ecole polytechnique, CNRS, INSERM, IP Paris
Jean Livet: Sorbonne Université, INSERM, CNRS, Institut de la Vision
Karine Loulier: Sorbonne Université, INSERM, CNRS, Institut de la Vision

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Astrocytes play essential roles in the neural tissue where they form a continuous network, while displaying important local heterogeneity. Here, we performed multiclonal lineage tracing using combinatorial genetic markers together with a new large volume color imaging approach to study astrocyte development in the mouse cortex. We show that cortical astrocyte clones intermix with their neighbors and display extensive variability in terms of spatial organization, number and subtypes of cells generated. Clones develop through 3D spatial dispersion, while at the individual level astrocytes acquire progressively their complex morphology. Furthermore, we find that the astroglial network is supplied both before and after birth by ventricular progenitors that scatter in the neocortex and can give rise to protoplasmic as well as pial astrocyte subtypes. Altogether, these data suggest a model in which astrocyte precursors colonize the neocortex perinatally in a non-ordered manner, with local environment likely determining astrocyte clonal expansion and final morphotype.

Date: 2019
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DOI: 10.1038/s41467-019-12791-5

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