A secreted metal-binding protein protects necrotrophic phytopathogens from reactive oxygen species

Lulu Liu, Virginie Gueguen-Chaignon, Isabelle R Gonçalves, Christine Rascle, Martine Rigault, Alia Dellagi, Elise Loisel, Nathalie Poussereau, Agnès Rodrigue, Laurent Terradot () and Guy Condemine ()
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Lulu Liu: Université de Lyon, INSA de Lyon
Virginie Gueguen-Chaignon: SFR BioSciences, UMS3444/US8
Isabelle R Gonçalves: Université de Lyon, INSA de Lyon
Christine Rascle: Université de Lyon, INSA de Lyon
Martine Rigault: UMR1318 INRA-AgroParisTech
Alia Dellagi: UMR1318 INRA-AgroParisTech
Elise Loisel: Université de Lyon, INSA de Lyon
Nathalie Poussereau: Université de Lyon, INSA de Lyon
Agnès Rodrigue: Université de Lyon, INSA de Lyon
Laurent Terradot: Université de Lyon
Guy Condemine: Université de Lyon, INSA de Lyon

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Few secreted proteins involved in plant infection common to necrotrophic bacteria, fungi and oomycetes have been identified except for plant cell wall-degrading enzymes. Here we study a family of iron-binding proteins that is present in Gram-negative and Gram-positive bacteria, fungi, oomycetes and some animals. Homolog proteins in the phytopathogenic bacterium Dickeya dadantii (IbpS) and the fungal necrotroph Botrytis cinerea (BcIbp) are involved in plant infection. IbpS is secreted, can bind iron and copper, and protects the bacteria against H2O2-induced death. Its 1.7 Å crystal structure reveals a classical Venus Fly trap fold that forms dimers in solution and in the crystal. We propose that secreted Ibp proteins binds exogenous metals and thus limit intracellular metal accumulation and ROS formation in the microorganisms.

Date: 2019
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DOI: 10.1038/s41467-019-12826-x

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