Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection

Anthony R. D’Amato, Devan L. Puhl, Samuel A. T. Ellman, Bailey Balouch, Ryan J. Gilbert () and Edmund F. Palermo ()
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Anthony R. D’Amato: Rensselaer Polytechnic Institute
Devan L. Puhl: Rensselaer Polytechnic Institute
Samuel A. T. Ellman: Rensselaer Polytechnic Institute
Bailey Balouch: Rensselaer Polytechnic Institute
Ryan J. Gilbert: Rensselaer Polytechnic Institute
Edmund F. Palermo: Rensselaer Polytechnic Institute

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Central nervous system (CNS) injuries persist for years, and currently there are no therapeutics that can address the complex injury cascade that develops over this time-scale. 17β-estradiol (E2) has broad tropism within the CNS, targeting and inducing beneficial phenotypic changes in myriad cells following injury. To address the unmet need for vastly prolonged E2 release, we report first-generation poly(pro-E2) biomaterial scaffolds that release E2 at nanomolar concentrations over the course of 1–10 years via slow hydrolysis in vitro. As a result of their finely tuned properties, these scaffolds demonstrate the ability to promote and guide neurite extension ex vivo and protect neurons from oxidative stress in vitro. The design and testing of these materials reported herein demonstrate the first step towards next-generation implantable biomaterials with prolonged release and excellent regenerative potential.

Date: 2019
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DOI: 10.1038/s41467-019-12835-w

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