Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour

Bernd Bufe, Yannick Teuchert, Andreas Schmid, Martina Pyrski, Anabel Pérez-Gómez, Janina Eisenbeis, Thomas Timm, Tomohiro Ishii, Günter Lochnit, Markus Bischoff, Peter Mombaerts, Trese Leinders-Zufall and Frank Zufall ()
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Bernd Bufe: Saarland University
Yannick Teuchert: Saarland University
Andreas Schmid: Saarland University
Martina Pyrski: Saarland University
Anabel Pérez-Gómez: Saarland University
Janina Eisenbeis: Saarland University
Thomas Timm: Justus-Liebig-University Giessen
Tomohiro Ishii: Max Planck Research Unit for Neurogenetics
Günter Lochnit: Justus-Liebig-University Giessen
Markus Bischoff: Saarland University
Peter Mombaerts: Max Planck Research Unit for Neurogenetics
Trese Leinders-Zufall: Saarland University
Frank Zufall: Saarland University

Nature Communications, 2019, vol. 10, issue 1, 1-16

Abstract: Abstract Innate immune chemoreceptors of the formyl peptide receptor (Fpr) family are expressed by vomeronasal sensory neurons (VSNs) in the accessory olfactory system. Their biological function and coding mechanisms remain unknown. We show that mouse Fpr3 (Fpr-rs1) recognizes the core peptide motif f-MKKFRW that is predominantly present in the signal sequence of the bacterial protein MgrB, a highly conserved regulator of virulence and antibiotic resistance in Enterobacteriaceae. MgrB peptide can be produced and secreted by bacteria, and is selectively recognized by a subset of VSNs. Exposure to the peptide also stimulates VSNs in freely behaving mice and drives innate avoidance. Our data shows that Fpr3 is required for neuronal detection and avoidance of peptides derived from a conserved master virulence regulator of enteric bacteria.

Date: 2019
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DOI: 10.1038/s41467-019-12842-x

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