The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity

Bo Li (), Marco Aurélio Ferreira, Mengling Huang, Luiz Fernando Camargos, Xiao Yu, Ruan M. Teixeira, Paola A. Carpinetti, Giselle C. Mendes, Bianca C. Gouveia-Mageste, Chenglong Liu, Claudia S. L. Pontes, Otávio J. B. Brustolini, Laura G. C. Martins, Bruno P. Melo, Christiane E. M. Duarte, Libo Shan, Ping He and Elizabeth P. B. Fontes ()
Additional contact information
Bo Li: Huazhong Agricultural University
Marco Aurélio Ferreira: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
Mengling Huang: Huazhong Agricultural University
Luiz Fernando Camargos: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
Xiao Yu: Texas A&M University
Ruan M. Teixeira: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
Paola A. Carpinetti: Universidade Federal de Viçosa
Giselle C. Mendes: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
Bianca C. Gouveia-Mageste: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
Chenglong Liu: Texas A&M University
Claudia S. L. Pontes: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
Otávio J. B. Brustolini: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
Laura G. C. Martins: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
Bruno P. Melo: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
Christiane E. M. Duarte: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro
Libo Shan: Texas A&M University
Ping He: Texas A&M University
Elizabeth P. B. Fontes: National Institute of Science and Technology in Plant–Pest Interactions, Bioagro

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Plants deploy various immune receptors to recognize pathogens and defend themselves. Crosstalk may happen among receptor-mediated signal transduction pathways in the same host during simultaneous infection of different pathogens. However, the related function of the receptor-like kinases (RLKs) in thwarting different pathogens remains elusive. Here, we report that NIK1, which positively regulates plant antiviral immunity, acts as an important negative regulator of antibacterial immunity. nik1 plants exhibit dwarfed morphology, enhanced disease resistance to bacteria and increased PAMP-triggered immunity (PTI) responses, which are restored by NIK1 reintroduction. Additionally, NIK1 negatively regulates the formation of the FLS2/BAK1 complex. The interaction between NIK1 and FLS2/BAK1 is enhanced upon flg22 perception, revealing a novel PTI regulatory mechanism by an RLK. Furthermore, flg22 perception induces NIK1 and RPL10A phosphorylation in vivo, activating antiviral signalling. The NIK1-mediated inverse modulation of antiviral and antibacterial immunity may allow bacteria and viruses to activate host immune responses against each other.

Date: 2019
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DOI: 10.1038/s41467-019-12847-6

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