A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging

Hong-Wei An, Li-Li Li, Yi Wang, Ziqi Wang, Dayong Hou, Yao-Xin Lin, Sheng-Lin Qiao, Man-Di Wang, Chao Yang, Yong Cong, Yang Ma, Xiao-Xiao Zhao, Qian Cai, Wen-Ting Chen, Chu-Qi Lu, Wanhai Xu (), Hao Wang () and Yuliang Zhao ()
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Hong-Wei An: National Center for Nanoscience and Technology (NCNST)
Li-Li Li: National Center for Nanoscience and Technology (NCNST)
Yi Wang: National Center for Nanoscience and Technology (NCNST)
Ziqi Wang: Heilongjiang Key Laboratory of Scientific Research in Urology
Dayong Hou: Heilongjiang Key Laboratory of Scientific Research in Urology
Yao-Xin Lin: National Center for Nanoscience and Technology (NCNST)
Sheng-Lin Qiao: National Center for Nanoscience and Technology (NCNST)
Man-Di Wang: National Center for Nanoscience and Technology (NCNST)
Chao Yang: National Center for Nanoscience and Technology (NCNST)
Yong Cong: National Center for Nanoscience and Technology (NCNST)
Yang Ma: National Center for Nanoscience and Technology (NCNST)
Xiao-Xiao Zhao: National Center for Nanoscience and Technology (NCNST)
Qian Cai: National Center for Nanoscience and Technology (NCNST)
Wen-Ting Chen: National Center for Nanoscience and Technology (NCNST)
Chu-Qi Lu: National Center for Nanoscience and Technology (NCNST)
Wanhai Xu: Heilongjiang Key Laboratory of Scientific Research in Urology
Hao Wang: National Center for Nanoscience and Technology (NCNST)
Yuliang Zhao: National Center for Nanoscience and Technology (NCNST)

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes and therapeutics. We show in different mouse models that the TCASS system accumulates in solid tumours. The molecules show enhanced accumulation in tumour regions via the effect of recognition induced self-assembly. Analysis of the molecular penetration in tumour tissue shows that in vivo self-assembly increases the penetration capability compared to typical soft or hard nanomaterials. Importantly, the in vivo self-assembled molecules exhibit a comparable clearance pathway to that of small molecules, which are excreted from organs of the reticuloendothelial system (liver and kidney), while are relatively slowly eliminated from tumour tissues. Finally, this system, combined with the NIR probe, shows high specificity and sensitivity for detecting bladder cancer in isolated intact patient bladders.

Date: 2019
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DOI: 10.1038/s41467-019-12848-5

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