Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus

Xuming Chen, Filip Sobczak, Yi Chen, Yuanyuan Jiang, Chunqi Qian, Zuneng Lu, Cenk Ayata, Nikos K. Logothetis and Xin Yu ()
Additional contact information
Xuming Chen: Max Planck Institute for Biological Cybernetics
Filip Sobczak: Max Planck Institute for Biological Cybernetics
Yi Chen: Max Planck Institute for Biological Cybernetics
Yuanyuan Jiang: Max Planck Institute for Biological Cybernetics
Chunqi Qian: Michigan State University
Zuneng Lu: Wuhan University, Renmin Hospital
Cenk Ayata: Massachusetts General Hospital, Harvard Medical School
Nikos K. Logothetis: Max Planck Institute for Biological Cybernetics
Xin Yu: Max Planck Institute for Biological Cybernetics

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Extensive in vivo imaging studies investigate the hippocampal neural network function, mainly focusing on the dorsal CA1 region given its optical accessibility. Multi-modality fMRI with simultaneous hippocampal electrophysiological recording reveal broad cortical correlation patterns, but the detailed spatial hippocampal functional map remains lacking given the limited fMRI resolution. In particular, hemodynamic responses linked to specific neural activity are unclear at the single-vessel level across hippocampal vasculature, which hinders the deciphering of the hippocampal malfunction in animal models and the translation to critical neurovascular coupling (NVC) patterns for human fMRI. We simultaneously acquired optogenetically-driven neuronal Ca2+ signals with single-vessel blood-oxygen-level-dependent (BOLD) and cerebral-blood-volume (CBV)-fMRI from individual venules and arterioles. Distinct spatiotemporal patterns of hippocampal hemodynamic responses were correlated to optogenetically evoked and spreading depression-like calcium events. The calcium event-related single-vessel hemodynamic modeling revealed significantly reduced NVC efficiency upon spreading depression-like (SDL) events, providing a direct measure of the NVC function at various hippocampal states.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-019-12850-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12850-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-12850-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().