Intestinal microbiome composition and its relation to joint pain and inflammation

Cindy G. Boer, Djawad Radjabzadeh, Carolina Medina-Gomez, Sanzhima Garmaeva, Dieuwke Schiphof, Pascal Arp, Thomas Koet, Alexander Kurilshikov, Jingyuan Fu, M. Arfan Ikram, Sita Bierma-Zeinstra, André G. Uitterlinden, Robert Kraaij, Alexandra Zhernakova and Joyce B. J. van Meurs ()
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Cindy G. Boer: Erasmus MC, University Medical Center
Djawad Radjabzadeh: Erasmus MC, University Medical Center
Carolina Medina-Gomez: Erasmus MC, University Medical Center
Sanzhima Garmaeva: University of Groningen
Dieuwke Schiphof: University Medical Center
Pascal Arp: Erasmus MC, University Medical Center
Thomas Koet: Erasmus MC, University Medical Center
Alexander Kurilshikov: University of Groningen
Jingyuan Fu: University of Groningen
M. Arfan Ikram: University Medical Center Rotterdam
Sita Bierma-Zeinstra: University Medical Center
André G. Uitterlinden: Erasmus MC, University Medical Center
Robert Kraaij: Erasmus MC, University Medical Center
Alexandra Zhernakova: University of Groningen
Joyce B. J. van Meurs: Erasmus MC, University Medical Center

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.

Date: 2019
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DOI: 10.1038/s41467-019-12873-4

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