The oomycete Lagenisma coscinodisci hijacks host alkaloid synthesis during infection of a marine diatom

Marine Vallet (), Tim U. H. Baumeister, Filip Kaftan, Veit Grabe, Anthony Buaya, Marco Thines, Aleš Svatoš and Georg Pohnert ()
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Marine Vallet: Max Planck Institute for Chemical Ecology
Tim U. H. Baumeister: Max Planck Institute for Chemical Ecology
Filip Kaftan: Max Planck Institute for Chemical Ecology
Veit Grabe: Max Planck Institute for Chemical Ecology
Anthony Buaya: Senckenberg Biodiversity and Climate Research Centre
Marco Thines: Senckenberg Biodiversity and Climate Research Centre
Aleš Svatoš: Max Planck Institute for Chemical Ecology
Georg Pohnert: Max Planck Institute for Chemical Ecology

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract Flagellated oomycetes frequently infect unicellular algae, thus limiting their proliferation. Here we show that the marine oomycete Lagenisma coscinodisci rewires the metabolome of the bloom-forming diatom Coscinodiscus granii, thereby promoting infection success. The algal alkaloids β-carboline and 2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid are induced during infection. Single-cell profiling with AP-MALDI-MS and confocal laser scanning microscopy reveals that algal carbolines accumulate in the reproductive form of the parasite. The compounds arrest the algal cell division, increase the infection rate and induce plasmolysis in the host. Our results indicate that the oomycete manipulates the host metabolome to support its own multiplication.

Date: 2019
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DOI: 10.1038/s41467-019-12908-w

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