Biological process activity transformation of single cell gene expression for cross-species alignment

Hongxu Ding (), Andrew Blair, Ying Yang and Joshua M. Stuart ()
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Hongxu Ding: University of California
Andrew Blair: University of California
Ying Yang: Columbia University Medical Center
Joshua M. Stuart: University of California

Nature Communications, 2019, vol. 10, issue 1, 1-6

Abstract: Abstract The maintenance and transition of cellular states are controlled by biological processes. Here we present a gene set-based transformation of single cell RNA-Seq data into biological process activities that provides a robust description of cellular states. Moreover, as these activities represent species-independent descriptors, they facilitate the alignment of single cell states across different organisms.

Date: 2019
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DOI: 10.1038/s41467-019-12924-w

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