Active generation of nanoholes in DNA origami scaffolds for programmed catalysis in nanocavities

Jianbang Wang, Liang Yue, Ziyuan Li, Junji Zhang, He Tian and Itamar Willner ()
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Jianbang Wang: The Hebrew University of Jerusalem
Liang Yue: The Hebrew University of Jerusalem
Ziyuan Li: East China University of Science and Technology
Junji Zhang: East China University of Science and Technology
He Tian: East China University of Science and Technology
Itamar Willner: The Hebrew University of Jerusalem

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract DNA origami tiles provide nanostructures for the spatial and temporal control of functional loads on the scaffolds. Here we introduce the active generation of nanoholes in the origami scaffolds using DNAzymes or light as triggers and present the programmed and switchable catalysis in the resulting nanocavities. We engineer “window” domains locked into the origami scaffolds by substrates of the Zn2+-ion- or Pb2+-ion-dependent DNAzymes. Using Zn2+ ions and/or Pb2+ ions, the programmed unlocking of the “window” domains is demonstrated. The tailored functionalization of the origami scaffolds allows the programmed operation of catalytic processes in the confined nanocavities. Also, the “window” domain is integrated into the origami scaffold using photoisomerizable azobenzene-modified locks. The cyclic photoisomerization of the locks between the cis and trans states leads to a reversible opening and closure of the nanoholes and to the cyclic light-induced switching of catalytic processes in the nanocavities.

Date: 2019
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DOI: 10.1038/s41467-019-12933-9

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