Complex I is bypassed during high intensity exercise

Avlant Nilsson, Elias Björnson, Mikael Flockhart, Filip J. Larsen and Jens Nielsen ()
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Avlant Nilsson: Chalmers University of Technology
Elias Björnson: Chalmers University of Technology
Mikael Flockhart: Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences
Filip J. Larsen: Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences
Jens Nielsen: Chalmers University of Technology

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Human muscles are tailored towards ATP synthesis. When exercising at high work rates muscles convert glucose to lactate, which is less nutrient efficient than respiration. There is hence a trade-off between endurance and power. Metabolic models have been developed to study how limited catalytic capacity of enzymes affects ATP synthesis. Here we integrate an enzyme-constrained metabolic model with proteomics data from muscle fibers. We find that ATP synthesis is constrained by several enzymes. A metabolic bypass of mitochondrial complex I is found to increase the ATP synthesis rate per gram of protein compared to full respiration. To test if this metabolic mode occurs in vivo, we conduct a high resolved incremental exercise tests for five subjects. Their gas exchange at different work rates is accurately reproduced by a whole-body metabolic model incorporating complex I bypass. The study therefore shows how proteome allocation influences metabolism during high intensity exercise.

Date: 2019
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DOI: 10.1038/s41467-019-12934-8

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