Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium

Jingqiang Wang, Daisong Wang, Kun Chu, Wen Li () and Yi Arial Zeng ()
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Jingqiang Wang: University of Chinese Academy of Sciences
Daisong Wang: University of Chinese Academy of Sciences
Kun Chu: Second Military Medical University
Wen Li: Second Military Medical University
Yi Arial Zeng: University of Chinese Academy of Sciences

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Ovarian surface epithelium (OSE) undergoes recurring ovulatory rupture and repair. The OSE replenishing mechanism post ovulation remains unclear. Here we report that the expression of Protein C Receptor (Procr) marks a progenitor population in adult mice that is responsible for OSE repair post ovulation. Procr+ cells are the major cell source for OSE repair. The mechanism facilitating the rapid re-epithelialization is through the immediate expansion of Procr+ cells upon OSE rupture. Targeted ablation of Procr+ cells impedes the repairing process. Moreover, Procr+ cells displayed robust colony-formation capacity in culture, which we harnessed and established a long-term culture and expansion system of OSE cells. Finally, we show that Procr+ cells and previously reported Lgr5+ cells have distinct lineage tracing behavior in OSE homeostasis. Our study suggests that Procr marks progenitor cells that are critical for OSE ovulatory rupture and homeostasis, providing insight into how adult stem cells respond upon injury.

Date: 2019
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DOI: 10.1038/s41467-019-12935-7

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