Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Raymond Noordam (), Maxime M. Bos, Heming Wang, Thomas W. Winkler, Amy R. Bentley, Tuomas O. Kilpeläinen, Paul S. Vries, Yun Ju Sung, Karen Schwander, Brian E. Cade, Alisa Manning, Hugues Aschard, Michael R. Brown, Han Chen, Nora Franceschini, Solomon K. Musani, Melissa Richard, Dina Vojinovic, Stella Aslibekyan, Traci M. Bartz, Lisa las Fuentes, Mary Feitosa, Andrea R. Horimoto, Marjan Ilkov, Minjung Kho, Aldi Kraja, Changwei Li, Elise Lim, Yongmei Liu, Dennis O. Mook-Kanamori, Tuomo Rankinen, Salman M. Tajuddin, Ashley Spek, Zhe Wang, Jonathan Marten, Vincent Laville, Maris Alver, Evangelos Evangelou, Maria E. Graff, Meian He, Brigitte Kühnel, Leo-Pekka Lyytikäinen, Pedro Marques-Vidal, Ilja M. Nolte, Nicholette D. Palmer, Rainer Rauramaa, Xiao-Ou Shu, Harold Snieder, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Correa Adolfo, Christie Ballantyne, Larry Bielak, Nienke R. Biermasz, Eric Boerwinkle, Niki Dimou, Gudny Eiriksdottir, Chuan Gao, Sina A. Gharib, Daniel J. Gottlieb, José Haba-Rubio, Tamara B. Harris, Sami Heikkinen, Raphaël Heinzer, James E. Hixson, Georg Homuth, M. Arfan Ikram, Pirjo Komulainen, Jose E. Krieger, Jiwon Lee, Jingmin Liu, Kurt K. Lohman, Annemarie I. Luik, Reedik Mägi, Lisa W. Martin, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Mike A. Nalls, Jeff O’Connell, Annette Peters, Patricia Peyser, Olli T. Raitakari, Alex P. Reiner, Patrick C. N. Rensen, Treva K. Rice, Stephen S. Rich, Till Roenneberg, Jerome I. Rotter, Pamela J. Schreiner, James Shikany, Stephen S. Sidney, Mario Sims, Colleen M. Sitlani, Tamar Sofer, Konstantin Strauch, Morris A. Swertz, Kent D. Taylor, André G. Uitterlinden, Cornelia M. Duijn, Henry Völzke, Melanie Waldenberger, Robert B. Wallance, Ko Willems Dijk, Caizheng Yu, Alan B. Zonderman, Diane M. Becker, Paul Elliott, Tõnu Esko, Christian Gieger, Hans J. Grabe, Timo A. Lakka, Terho Lehtimäki, Kari E. North, Brenda W. J. H. Penninx, Peter Vollenweider, Lynne E. Wagenknecht, Tangchun Wu, Yong-Bing Xiang, Wei Zheng, Donna K. Arnett, Claude Bouchard, Michele K. Evans, Vilmundur Gudnason, Sharon Kardia, Tanika N. Kelly, Stephen B. Kritchevsky, Ruth J. F. Loos, Alexandre C. Pereira, Mike Province, Bruce M. Psaty, Charles Rotimi, Xiaofeng Zhu, Najaf Amin, L. Adrienne Cupples, Myriam Fornage, Ervin F. Fox, Xiuqing Guo, W. James Gauderman, Kenneth Rice, Charles Kooperberg, Patricia B. Munroe, Ching-Ti Liu, Alanna C. Morrison, Dabeeru C. Rao, Diana Heemst and Susan Redline ()
Additional contact information
Raymond Noordam: Leiden University Medical Center
Maxime M. Bos: Leiden University Medical Center
Heming Wang: Brigham and Women’s Hospital
Thomas W. Winkler: University of Regensburg
Amy R. Bentley: National Institutes of Health
Tuomas O. Kilpeläinen: University of Copenhagen
Paul S. Vries: The University of Texas Health Science Center at Houston
Yun Ju Sung: Washington University School of Medicine
Karen Schwander: Washington University School of Medicine
Brian E. Cade: Brigham and Women’s Hospital
Alisa Manning: Massachusetts General Hospital
Hugues Aschard: Harvard School of Public Health
Michael R. Brown: The University of Texas Health Science Center at Houston
Han Chen: The University of Texas Health Science Center at Houston
Nora Franceschini: University of North Carolina
Solomon K. Musani: University of Mississippi Medical Center
Melissa Richard: The University of Texas Health Science Center at Houston
Dina Vojinovic: Erasmus University Medical Center
Stella Aslibekyan: University of Alabama at Birmingham
Traci M. Bartz: University of Washington
Lisa las Fuentes: Washington University School of Medicine
Mary Feitosa: Washington University School of Medicine
Andrea R. Horimoto: University of São Paulo Medical School
Marjan Ilkov: Icelandic Heart Association
Minjung Kho: University of Michigan
Aldi Kraja: Washington University School of Medicine
Changwei Li: University of Georgia at Athens College of Public Health
Elise Lim: Boston University School of Public Health
Yongmei Liu: Wake Forest University Health Sciences
Dennis O. Mook-Kanamori: Leiden University Medical Center
Tuomo Rankinen: Pennington Biomedical Research Center
Salman M. Tajuddin: National Institutes of Health
Ashley Spek: Erasmus University Medical Center
Zhe Wang: The University of Texas Health Science Center at Houston
Jonathan Marten: University of Edinburgh
Vincent Laville: Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur
Maris Alver: University of Tartu
Evangelos Evangelou: Imperial College London
Maria E. Graff: University of North Carolina
Meian He: Huazhong University of Science and Technology
Brigitte Kühnel: German Research Center for Environmental Health
Leo-Pekka Lyytikäinen: Fimlab Laboratories
Pedro Marques-Vidal: Lausanne University Hospital
Ilja M. Nolte: University of Groningen, University Medical Center Groningen, Department of Epidemiology
Nicholette D. Palmer: Biochemistry, Wake Forest School of Medicine
Rainer Rauramaa: Kuopio Research Institute of Exercise Medicine
Xiao-Ou Shu: Vanderbilt University School of Medicine
Harold Snieder: University of Groningen, University Medical Center Groningen, Department of Epidemiology
Stefan Weiss: University Medicine Greifswald
Wanqing Wen: Vanderbilt University School of Medicine
Lisa R. Yanek: Johns Hopkins University School of Medicine
Correa Adolfo: University of Mississippi Medical Center
Christie Ballantyne: Baylor College of Medicine
Larry Bielak: University of Michigan
Nienke R. Biermasz: Leiden University Medical Center
Eric Boerwinkle: The University of Texas Health Science Center at Houston
Niki Dimou: University of Ioannina Medical School
Gudny Eiriksdottir: Icelandic Heart Association
Chuan Gao: Wake Forest School of Medicine
Sina A. Gharib: University of Washington
Daniel J. Gottlieb: Brigham and Women’s Hospital
José Haba-Rubio: Lausanne University Hospital
Tamara B. Harris: National Institutes of Health
Sami Heikkinen: University of Eastern Finland
Raphaël Heinzer: Lausanne University Hospital
James E. Hixson: The University of Texas Health Science Center at Houston
Georg Homuth: University Medicine Greifswald
M. Arfan Ikram: Erasmus University Medical Center
Pirjo Komulainen: Kuopio Research Institute of Exercise Medicine
Jose E. Krieger: University of São Paulo Medical School
Jiwon Lee: Brigham and Women’s Hospital
Jingmin Liu: University of Washington School of Public Health
Kurt K. Lohman: Wake Forest University Health Sciences
Annemarie I. Luik: Erasmus University Medical Center
Reedik Mägi: University of Tartu
Lisa W. Martin: George Washington University
Thomas Meitinger: German Research Center for Environmental Health
Andres Metspalu: University of Tartu
Yuri Milaneschi: George Washington University
Mike A. Nalls: National Institute on Aging
Jeff O’Connell: University of Maryland School of Medicine
Annette Peters: German Research Center for Environmental Health
Patricia Peyser: University of Michigan
Olli T. Raitakari: Turku University Hospital
Alex P. Reiner: University of Washington School of Public Health
Patrick C. N. Rensen: Leiden University Medical Center
Treva K. Rice: Washington University School of Medicine
Stephen S. Rich: University of Virginia
Till Roenneberg: Ludwig-Maximilians-Universitat Munchen
Jerome I. Rotter: LABioMed at Harbor-UCLA Medical Center
Pamela J. Schreiner: University of Minnesota
James Shikany: University of Alabama at Birmingham
Stephen S. Sidney: Division of Research, Kaiser Permanente Northern California
Mario Sims: University of Mississippi Medical Center
Colleen M. Sitlani: University of Washington
Tamar Sofer: Brigham and Women’s Hospital
Konstantin Strauch: German Research Center for Environmental Health
Morris A. Swertz: University of Groningen, University Medical Center Groningen, Department of Genetics
Kent D. Taylor: LABioMed at Harbor-UCLA Medical Center
André G. Uitterlinden: Erasmus University Medical Center
Cornelia M. Duijn: Erasmus University Medical Center
Henry Völzke: University Medicine Greifswald
Melanie Waldenberger: German Research Center for Environmental Health
Robert B. Wallance: University of Iowa College of Public Health
Ko Willems Dijk: Leiden University Medical Center
Caizheng Yu: Huazhong University of Science and Technology
Alan B. Zonderman: National Institute on Aging, National Institutes of Health
Diane M. Becker: Johns Hopkins University School of Medicine
Paul Elliott: University of Tartu
Tõnu Esko: University of Tartu
Christian Gieger: German Research Center for Environmental Health
Hans J. Grabe: University Medicine Greifswald
Timo A. Lakka: Kuopio Research Institute of Exercise Medicine
Terho Lehtimäki: Fimlab Laboratories
Kari E. North: University of North Carolina
Brenda W. J. H. Penninx: Amsterdam UMC, Vrije Universiteit
Peter Vollenweider: Lausanne University Hospital
Lynne E. Wagenknecht: Wake Forest School of Medicine
Tangchun Wu: Huazhong University of Science and Technology
Yong-Bing Xiang: Shanghai Jiaotong University School of Medicine
Wei Zheng: Vanderbilt University School of Medicine
Donna K. Arnett: University of Kentucky College of Public Health
Claude Bouchard: Pennington Biomedical Research Center
Michele K. Evans: National Institutes of Health
Vilmundur Gudnason: Icelandic Heart Association
Sharon Kardia: University of Michigan
Tanika N. Kelly: Epidemiology, Tulane University School of Public Health and Tropical Medicine
Stephen B. Kritchevsky: Wake Forest School of Medicine
Ruth J. F. Loos: The Icahn School of Medicine at Mount Sinai
Alexandre C. Pereira: University of São Paulo Medical School
Mike Province: Washington University School of Medicine
Bruce M. Psaty: University of Washington
Charles Rotimi: National Institutes of Health
Xiaofeng Zhu: Case Western Reserve University
Najaf Amin: Erasmus University Medical Center
L. Adrienne Cupples: Boston University School of Public Health
Myriam Fornage: The University of Texas Health Science Center at Houston
Ervin F. Fox: University of Mississippi Medical Center
Xiuqing Guo: LABioMed at Harbor-UCLA Medical Center
W. James Gauderman: University of Southern California
Kenneth Rice: University of Washington
Charles Kooperberg: University of Washington School of Public Health
Patricia B. Munroe: Queen Mary University of London
Ching-Ti Liu: Boston University School of Public Health
Alanna C. Morrison: The University of Texas Health Science Center at Houston
Dabeeru C. Rao: Washington University School of Medicine
Diana Heemst: Leiden University Medical Center
Susan Redline: Brigham and Women’s Hospital

Nature Communications, 2019, vol. 10, issue 1, 1-13

Abstract: Abstract Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.

Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-019-12958-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12958-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-019-12958-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().