Rapid mechanochemical encapsulation of biocatalysts into robust metal–organic frameworks

Tz-Han Wei, Shi-Hong Wu, Yi-Da Huang, Wei-Shang Lo, Benjamin P. Williams, Sheng-Yu Chen, Hsun-Chih Yang, Yu-Shen Hsu, Zih-Yin Lin, Xin-Hua Chen, Pei-En Kuo, Lien-Yang Chou (), Chia-Kuang Tsung () and Fa-Kuen Shieh ()
Additional contact information
Tz-Han Wei: ShanghaiTech University
Shi-Hong Wu: National Central University
Yi-Da Huang: National Central University
Wei-Shang Lo: Merkert Chemistry Center, Boston College
Benjamin P. Williams: Merkert Chemistry Center, Boston College
Sheng-Yu Chen: ShanghaiTech University
Hsun-Chih Yang: National Central University
Yu-Shen Hsu: National Central University
Zih-Yin Lin: National Central University
Xin-Hua Chen: National Central University
Pei-En Kuo: National Central University
Lien-Yang Chou: ShanghaiTech University
Chia-Kuang Tsung: Merkert Chemistry Center, Boston College
Fa-Kuen Shieh: National Central University

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract Metal–organic frameworks (MOFs) have recently garnered consideration as an attractive solid substrate because the highly tunable MOF framework can not only serve as an inert host but also enhance the selectivity, stability, and/or activity of the enzymes. Herein, we demonstrate the advantages of using a mechanochemical strategy to encapsulate enzymes into robust MOFs. A range of enzymes, namely β-glucosidase, invertase, β-galactosidase, and catalase, are encapsulated in ZIF-8, UiO-66-NH2, or Zn-MOF-74 via a ball milling process. The solid-state mechanochemical strategy is rapid and minimizes the use of organic solvents and strong acids during synthesis, allowing the encapsulation of enzymes into three prototypical robust MOFs while maintaining enzymatic biological activity. The activity of encapsulated enzyme is demonstrated and shows increased resistance to proteases, even under acidic conditions. This work represents a step toward the creation of a suite of biomolecule-in-MOF composites for application in a variety of industrial processes.

Date: 2019
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DOI: 10.1038/s41467-019-12966-0

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