Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Merel C. Postema, Daan Rooij, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Geraldo Busatto Filho, Sara Calderoni, Rosa Calvo, Eileen Daly, Christine Deruelle, Adriana Martino, Ilan Dinstein, Fabio Luis S. Duran, Sarah Durston, Christine Ecker, Stefan Ehrlich, Damien Fair, Jennifer Fedor, Xin Feng, Jackie Fitzgerald, Dorothea L. Floris, Christine M. Freitag, Louise Gallagher, David C. Glahn, Ilaria Gori, Shlomi Haar, Liesbeth Hoekstra, Neda Jahanshad, Maria Jalbrzikowski, Joost Janssen, Joseph A. King, Xiang Zhen Kong, Luisa Lazaro, Jason P. Lerch, Beatriz Luna, Mauricio M. Martinho, Jane McGrath, Sarah E. Medland, Filippo Muratori, Clodagh M. Murphy, Declan G. M. Murphy, Kirsten O’Hearn, Bob Oranje, Mara Parellada, Olga Puig, Alessandra Retico, Pedro Rosa, Katya Rubia, Devon Shook, Margot J. Taylor, Michela Tosetti, Gregory L. Wallace, Fengfeng Zhou, Paul M. Thompson, Simon E. Fisher, Jan K. Buitelaar and Clyde Francks ()
Additional contact information
Merel C. Postema: Max Planck Institute for Psycholinguistics
Daan Rooij: Radboud University Medical Centre
Evdokia Anagnostou: University of Toronto
Celso Arango: Universidad Complutense, IiSGM, CIBERSAM
Guillaume Auzias: Institut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université, CNRS
Marlene Behrmann: Carnegie Mellon University
Geraldo Busatto Filho: Universidade de Sao Paulo
Sara Calderoni: IRCCS Stella Maris Foundation, viale del Tirreno 331
Rosa Calvo: 2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM
Eileen Daly: Psychology & Neuroscience King’s College London
Christine Deruelle: Institut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université, CNRS
Adriana Martino: NYU Child Study Center
Ilan Dinstein: Ben-Gurion University of the Negev
Fabio Luis S. Duran: Universidade de Sao Paulo
Sarah Durston: University Medical Center Utrecht
Christine Ecker: Goethe University Frankfurt am Main
Stefan Ehrlich: TU Dresden
Damien Fair: Oregon Health & Science University
Jennifer Fedor: University of Pittsburgh
Xin Feng: Jilin University, Changchun
Jackie Fitzgerald: Trinity College
Dorothea L. Floris: Radboud University Medical Centre
Christine M. Freitag: Goethe University Frankfurt am Main
Louise Gallagher: Trinity College
David C. Glahn: Boston Children’s Hospital and Harvard Medical School
Ilaria Gori: Pisa Division, Largo B. Pontecorvo 3
Shlomi Haar: Imperial College London
Liesbeth Hoekstra: Radboud University Medical Centre
Neda Jahanshad: University of Southern California
Maria Jalbrzikowski: Trinity College
Joost Janssen: Universidad Complutense, IiSGM, CIBERSAM
Joseph A. King: TU Dresden
Xiang Zhen Kong: Max Planck Institute for Psycholinguistics
Luisa Lazaro: 2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM
Jason P. Lerch: The Hospital for Sick Children
Beatriz Luna: University of Pittsburgh
Mauricio M. Martinho: Universidade Federal de Santa Maria
Jane McGrath: Trinity College
Sarah E. Medland: QIMR Berghofer Medical Research Institute
Filippo Muratori: IRCCS Stella Maris Foundation, viale del Tirreno 331
Clodagh M. Murphy: Psychology & Neuroscience King’s College London
Declan G. M. Murphy: South London and Maudsley Foundation NHS Trust
Kirsten O’Hearn: University of Pittsburgh
Bob Oranje: University Medical Center Utrecht
Mara Parellada: Universidad Complutense, IiSGM, CIBERSAM
Olga Puig: 2017SGR881, University of Barcelona, IDIBAPS, CIBERSAM
Alessandra Retico: Pisa Division, Largo B. Pontecorvo 3
Pedro Rosa: Universidade de Sao Paulo
Katya Rubia: Kings College London
Devon Shook: University Medical Center Utrecht
Margot J. Taylor: University of Toronto
Michela Tosetti: IRCCS Stella Maris Foundation, viale del Tirreno 331
Gregory L. Wallace: The George Washington University
Fengfeng Zhou: Jilin University, Changchun
Paul M. Thompson: University of Southern California
Simon E. Fisher: Max Planck Institute for Psycholinguistics
Jan K. Buitelaar: Radboud University Medical Centre
Clyde Francks: Max Planck Institute for Psycholinguistics

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen’s d = −0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.

Date: 2019
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DOI: 10.1038/s41467-019-13005-8

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