Optical molecular imaging can differentiate metastatic from benign lymph nodes in head and neck cancer

Naoki Nishio, Nynke S. van den Berg, Stan van Keulen, Brock A. Martin, Shayan Fakurnejad, Nutte Teraphongphom, Stefania U. Chirita, Nicholas J. Oberhelman, Guolan Lu, Crista E. Horton, Michael J. Kaplan, Vasu Divi, A. Dimitrios Colevas and Eben L. Rosenthal ()
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Naoki Nishio: Stanford University School of Medicine
Nynke S. van den Berg: Stanford University School of Medicine
Stan van Keulen: Stanford University School of Medicine
Brock A. Martin: Stanford University School of Medicine
Shayan Fakurnejad: Stanford University School of Medicine
Nutte Teraphongphom: Stanford University School of Medicine
Stefania U. Chirita: Stanford University School of Medicine
Nicholas J. Oberhelman: Stanford University School of Medicine
Guolan Lu: Stanford University School of Medicine
Crista E. Horton: Stanford University School of Medicine
Michael J. Kaplan: Stanford University School of Medicine
Vasu Divi: Stanford University School of Medicine
A. Dimitrios Colevas: Stanford University School of Medicine
Eben L. Rosenthal: Stanford University School of Medicine

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation of fewer LNs. Here we evaluate the impact of a systemically injected, near-infrared fluorescently-labeled, tumor-targeting contrast agent, panitumumab-IRDye800CW, to facilitate the identification of metastatic LNs in the ex vivo setting for head and neck cancer patients. Molecular imaging demonstrates a significantly higher mean fluorescence signal in metastatic LNs compared to benign LNs in head and neck cancer patients undergoing an elective neck dissection. Molecular imaging to preselect at-risk LNs may thus allow a more rigorous examination of LNs and subsequently lead to improved prognostication than regular neck dissection.

Date: 2019
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DOI: 10.1038/s41467-019-13076-7

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