HPV infection and the genital cytokine milieu in women at high risk of HIV acquisition

Lenine J. P. Liebenberg (), Lyle R. McKinnon, Nonhlanhla Yende-Zuma, Nigel Garrett, Cheryl Baxter, Ayesha B. M. Kharsany, Derseree Archary, Anne Rositch, Natasha Samsunder, Leila E. Mansoor, Jo-Ann S. Passmore, Salim S. Abdool Karim and Quarraisha Abdool Karim
Additional contact information
Lenine J. P. Liebenberg: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Lyle R. McKinnon: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Nonhlanhla Yende-Zuma: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Nigel Garrett: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Cheryl Baxter: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Ayesha B. M. Kharsany: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Derseree Archary: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Anne Rositch: Johns Hopkins Bloomberg School of Public Health
Natasha Samsunder: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Leila E. Mansoor: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Jo-Ann S. Passmore: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Salim S. Abdool Karim: Centre for the AIDS Programme of Research in South Africa (CAPRISA)
Quarraisha Abdool Karim: Centre for the AIDS Programme of Research in South Africa (CAPRISA)

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Human papillomavirus (HPV) infection correlates with higher rates of HIV acquisition, but the underlying biological mechanisms are unclear. Here we study associations between HPV and HIV acquisition and relate these to vaginal cytokine profiles in an observational cohort of women at high risk of HIV infection (CAPRISA 004, n = 779) and with 74% HPV prevalence. We report here that HPV infection associates with a 2.5-fold increase in HIV acquisition risk in this population (95% CI: 1.2–5.3). Among 48 vaginal cytokines profiled, cytokines associated with HPV infection overlap substantially with cytokines associated with HIV risk, but are distinct from those observed in HPV negative women. Although our data do not establish a causative link between HPV status and the risk of HIV, we suggest that increasing HPV vaccination coverage may carry an additional benefit of reducing the risk of contracting HIV infection, particularly in regions with high HPV prevalence.

Date: 2019
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DOI: 10.1038/s41467-019-13089-2

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