Stroke among cancer patients

Nicholas G. Zaorsky (), Ying Zhang, Leila T. Tchelebi, Heath B. Mackley, Vernon M. Chinchilli and Brad E. Zacharia
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Nicholas G. Zaorsky: Penn State Cancer Institute
Ying Zhang: Penn State College of Medicine
Leila T. Tchelebi: Penn State Cancer Institute
Heath B. Mackley: Penn State Cancer Institute
Vernon M. Chinchilli: Penn State College of Medicine
Brad E. Zacharia: Penn State College of Medicine

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract We identify cancer patients at highest risk of fatal stroke. This is a population-based study using nationally representative data from the Surveillance, Epidemiology, and End Results program, 1992-2015. Among 7,529,481 cancer patients, 80,513 died of fatal stroke (with 262,461 person-years at risk); the rate of fatal stroke was 21.64 per 100,000-person years, and the standardized mortality ratio (SMR) of fatal stroke was 2.17 (95% CI, 2.15, 2.19). Patients with cancer of the prostate, breast, and colorectum contribute to the plurality of cancer patients dying of fatal stroke. Brain and gastrointestinal cancer patients had the highest SMRs (>2-5) through the follow up period. Among those diagnosed at 40, from cancers of the prostate, breast, and colorectum. For almost all cancers survivors, the risk of stroke increases with time.

Date: 2019
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DOI: 10.1038/s41467-019-13120-6

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