Stem-cell-ubiquitous genes spatiotemporally coordinate division through regulation of stem-cell-specific gene networks

Natalie M. Clark, Eli Buckner, Adam P. Fisher, Emily C. Nelson, Thomas T. Nguyen, Abigail R. Simmons, Maria A. Luis Balaguer, Tiara Butler-Smith, Parnell J. Sheldon, Dominique C. Bergmann, Cranos M. Williams and Rossangela Sozzani ()
Additional contact information
Natalie M. Clark: North Carolina State University
Eli Buckner: North Carolina State University
Adam P. Fisher: North Carolina State University
Emily C. Nelson: North Carolina State University
Thomas T. Nguyen: North Carolina State University
Abigail R. Simmons: Stanford University
Maria A. Luis Balaguer: North Carolina State University
Tiara Butler-Smith: North Carolina State University
Parnell J. Sheldon: North Carolina State University
Dominique C. Bergmann: Stanford University
Cranos M. Williams: North Carolina State University
Rossangela Sozzani: North Carolina State University

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract Stem cells are responsible for generating all of the differentiated cells, tissues, and organs in a multicellular organism and, thus, play a crucial role in cell renewal, regeneration, and organization. A number of stem cell type-specific genes have a known role in stem cell maintenance, identity, and/or division. Yet, how genes expressed across different stem cell types, referred to here as stem-cell-ubiquitous genes, contribute to stem cell regulation is less understood. Here, we find that, in the Arabidopsis root, a stem-cell-ubiquitous gene, TESMIN-LIKE CXC2 (TCX2), controls stem cell division by regulating stem cell-type specific networks. Development of a mathematical model of TCX2 expression allows us to show that TCX2 orchestrates the coordinated division of different stem cell types. Our results highlight that genes expressed across different stem cell types ensure cross-communication among cells, allowing them to divide and develop harmonically together.

Date: 2019
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DOI: 10.1038/s41467-019-13132-2

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