Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors

Jongha Lee, Hye Rim Cho, Gi Doo Cha, Hyunseon Seo, Seunghyun Lee, Chul-Kee Park, Jin Wook Kim, Shutao Qiao, Liu Wang, Dayoung Kang, Taegyu Kang, Tomotsugu Ichikawa, Jonghoon Kim, Hakyong Lee, Woongchan Lee, Sanghoek Kim, Soon-Tae Lee, Nanshu Lu, Taeghwan Hyeon, Seung Hong Choi () and Dae-Hyeong Kim ()
Additional contact information
Jongha Lee: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Hye Rim Cho: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Gi Doo Cha: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Hyunseon Seo: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Seunghyun Lee: Seoul National University College of Medicine
Chul-Kee Park: Seoul National University College of Medicine
Jin Wook Kim: Seoul National University College of Medicine
Shutao Qiao: University of Texas at Austin
Liu Wang: University of Texas at Austin
Dayoung Kang: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Taegyu Kang: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Tomotsugu Ichikawa: Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Jonghoon Kim: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Hakyong Lee: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Woongchan Lee: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Sanghoek Kim: Kyung Hee University
Soon-Tae Lee: Seoul National University College of Medicine
Nanshu Lu: University of Texas at Austin
Taeghwan Hyeon: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Seung Hong Choi: Center for Nanoparticle Research, Institute for Basic Science (IBS)
Dae-Hyeong Kim: Center for Nanoparticle Research, Institute for Basic Science (IBS)

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application.

Date: 2019
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DOI: 10.1038/s41467-019-13198-y

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