Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

Vasantha Basavalingappa, Santu Bera, Bin Xue, Ido Azuri, Yiming Tang, Kai Tao, Linda J. W. Shimon, Michael R. Sawaya, Sofiya Kolusheva, David S. Eisenberg, Leeor Kronik, Yi Cao, Guanghong Wei and Ehud Gazit ()
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Vasantha Basavalingappa: Tel Aviv University
Santu Bera: Tel Aviv University
Bin Xue: Nanjing University
Ido Azuri: Weizmann Institute of Science
Yiming Tang: Fudan University
Kai Tao: Tel Aviv University
Linda J. W. Shimon: Weizmann Institute of Science
Michael R. Sawaya: University of California, Los Angeles
Sofiya Kolusheva: Ben Gurion University of the Negev
David S. Eisenberg: University of California, Los Angeles
Leeor Kronik: Weizmann Institute of Science
Yi Cao: Nanjing University
Guanghong Wei: Fudan University
Ehud Gazit: Tel Aviv University

Nature Communications, 2019, vol. 10, issue 1, 1-11

Abstract: Abstract The variety and complexity of DNA-based structures make them attractive candidates for nanotechnology, yet insufficient stability and mechanical rigidity, compared to polyamide-based molecules, limit their application. Here, we combine the advantages of polyamide materials and the structural patterns inspired by nucleic-acids to generate a mechanically rigid fluorenylmethyloxycarbonyl (Fmoc)-guanine peptide nucleic acid (PNA) conjugate with diverse morphology and photoluminescent properties. The assembly possesses a unique atomic structure, with each guanine head of one molecule hydrogen bonded to the Fmoc carbonyl tail of another molecule, generating a non-planar cyclic quartet arrangement. This structure exhibits an average stiffness of 69.6 ± 6.8 N m−1 and Young’s modulus of 17.8 ± 2.5 GPa, higher than any previously reported nucleic acid derived structure. This data suggests that the unique cation-free “basket” formed by the Fmoc-G-PNA conjugate can serve as an attractive component for the design of new materials based on PNA self-assembly for nanotechnology applications.

Date: 2019
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DOI: 10.1038/s41467-019-13250-x

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