Sugar-mediated regulation of a c-di-GMP phosphodiesterase in Vibrio cholerae

Kyoo Heo, Young-Ha Park, Kyung-Ah Lee, Joonwon Kim, Hyeong-In Ham, Byung-Gee Kim, Won-Jae Lee and Yeong-Jae Seok ()
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Kyoo Heo: Seoul National University
Young-Ha Park: Seoul National University
Kyung-Ah Lee: Seoul National University
Joonwon Kim: Seoul National University
Hyeong-In Ham: Seoul National University
Byung-Gee Kim: Seoul National University
Won-Jae Lee: Seoul National University
Yeong-Jae Seok: Seoul National University

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Biofilm formation protects bacteria from stresses including antibiotics and host immune responses. Carbon sources can modulate biofilm formation and host colonization in Vibrio cholerae, but the underlying mechanisms remain unclear. Here, we show that EIIAGlc, a component of the phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS), regulates the intracellular concentration of the cyclic dinucleotide c-di-GMP, and thus biofilm formation. The availability of preferred sugars such as glucose affects EIIAGlc phosphorylation state, which in turn modulates the interaction of EIIAGlc with a c-di-GMP phosphodiesterase (hereafter referred to as PdeS). In a Drosophila model of V. cholerae infection, sugars in the host diet regulate gut colonization in a manner dependent on the PdeS-EIIAGlc interaction. Our results shed light into the mechanisms by which some nutrients regulate biofilm formation and host colonization.

Date: 2019
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DOI: 10.1038/s41467-019-13353-5

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