Carbon-nanotube reinforcement of DNA-silica nanocomposites yields programmable and cell-instructive biocoatings

Yong Hu, Carmen M. Domínguez, Jens Bauer, Simone Weigel, Alessa Schipperges, Claude Oelschlaeger, Norbert Willenbacher, Stephan Keppler, Martin Bastmeyer, Stefan Heißler, Christof Wöll, Tim Scharnweber, Kersten S. Rabe and Christof M. Niemeyer ()
Additional contact information
Yong Hu: Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG 1)
Carmen M. Domínguez: Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG 1)
Jens Bauer: Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG 1)
Simone Weigel: Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG 1)
Alessa Schipperges: Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG 1)
Claude Oelschlaeger: Karlsruhe Institute of Technology (KIT), Institute for Mechanical Process Engineering and Mechanics
Norbert Willenbacher: Karlsruhe Institute of Technology (KIT), Institute for Mechanical Process Engineering and Mechanics
Stephan Keppler: Zoological Institute
Martin Bastmeyer: Zoological Institute
Stefan Heißler: Karlsruhe Institute of Technology (KIT), Institute of Functional Interfaces (IFG)
Christof Wöll: Karlsruhe Institute of Technology (KIT), Institute of Functional Interfaces (IFG)
Tim Scharnweber: Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG 1)
Kersten S. Rabe: Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG 1)
Christof M. Niemeyer: Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG 1)

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Biomedical applications require substrata that allow for the grafting, colonization and control of eukaryotic cells. Currently available materials are often limited by insufficient possibilities for the integration of biological functions and means for tuning the mechanical properties. We report on tailorable nanocomposite materials in which silica nanoparticles are interwoven with carbon nanotubes by DNA polymerization. The modular, well controllable and scalable synthesis yields materials whose composition can be gradually adjusted to produce synergistic, non-linear mechanical stiffness and viscosity properties. The materials were exploited as substrata that outperform conventional culture surfaces in the ability to control cellular adhesion, proliferation and transmigration through the hydrogel matrix. The composite materials also enable the construction of layered cell architectures, the expansion of embryonic stem cells by simplified cultivation methods and the on-demand release of uniformly sized stem cell spheroids.

Date: 2019
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DOI: 10.1038/s41467-019-13381-1

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