Resettable skin interfaced microfluidic sweat collection devices with chemesthetic hydration feedback

Jonathan T. Reeder, Yeguang Xue, Daniel Franklin, Yujun Deng, Jungil Choi, Olivia Prado, Robin Kim, Claire Liu, Justin Hanson, John Ciraldo, Amay J. Bandodkar, Siddharth Krishnan, Alexandra Johnson, Emily Patnaude, Raudel Avila, Yonggang Huang and John A. Rogers ()
Additional contact information
Jonathan T. Reeder: Northwestern University
Yeguang Xue: Northwestern University
Daniel Franklin: Northwestern University
Yujun Deng: Northwestern University
Jungil Choi: Northwestern University
Olivia Prado: Northwestern University
Robin Kim: Northwestern University
Claire Liu: Northwestern University
Justin Hanson: Northwestern University
John Ciraldo: Northwestern University
Amay J. Bandodkar: Northwestern University
Siddharth Krishnan: University of Illinois at Urbana-Champaign
Alexandra Johnson: Kookmin University
Emily Patnaude: Kookmin University
Raudel Avila: Northwestern University
Yonggang Huang: Northwestern University
John A. Rogers: Northwestern University

Nature Communications, 2019, vol. 10, issue 1, 1-12

Abstract: Abstract Recently introduced classes of thin, soft, skin-mounted microfluidic systems offer powerful capabilities for continuous, real-time monitoring of total sweat loss, sweat rate and sweat biomarkers. Although these technologies operate without the cost, complexity, size, and weight associated with active components or power sources, rehydration events can render previous measurements irrelevant and detection of anomalous physiological events, such as high sweat loss, requires user engagement to observe colorimetric responses. Here we address these limitations through monolithic systems of pinch valves and suction pumps for purging of sweat as a reset mechanism to coincide with hydration events, microstructural optics for reversible readout of sweat loss, and effervescent pumps and chemesthetic agents for automated delivery of sensory warnings of excessive sweat loss. Human subject trials demonstrate the ability of these systems to alert users to the potential for dehydration via skin sensations initiated by sweat-triggered ejection of menthol and capsaicin.

Date: 2019
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DOI: 10.1038/s41467-019-13431-8

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