Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection

Matthew Magruder, Adam N. Sholi, Catherine Gong, Lisa Zhang, Emmanuel Edusei, Jennifer Huang, Shady Albakry, Michael J. Satlin, Lars F. Westblade, Carl Crawford, Darshana M. Dadhania, Michelle Lubetzky, Ying Taur, Eric Littman, Lilan Ling, Philip Burnham, Iwijn De Vlaminck, Eric Pamer, Manikkam Suthanthiran and John Richard Lee ()
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Matthew Magruder: Weill Cornell Medicine
Adam N. Sholi: Weill Cornell Medicine
Catherine Gong: Weill Cornell Medicine
Lisa Zhang: Weill Cornell Medicine
Emmanuel Edusei: Weill Cornell Medicine
Jennifer Huang: Weill Cornell Medicine
Shady Albakry: Weill Cornell Medicine
Michael J. Satlin: Weill Cornell Medicine
Lars F. Westblade: Weill Cornell Medicine
Carl Crawford: Weill Cornell Medicine
Darshana M. Dadhania: Weill Cornell Medicine
Michelle Lubetzky: Weill Cornell Medicine
Ying Taur: Memorial Sloan Kettering Cancer Center
Eric Littman: Memorial Sloan Kettering Cancer Center
Lilan Ling: Memorial Sloan Kettering Cancer Center
Philip Burnham: Cornell University
Iwijn De Vlaminck: Cornell University
Eric Pamer: Memorial Sloan Kettering Cancer Center
Manikkam Suthanthiran: Weill Cornell Medicine
John Richard Lee: Weill Cornell Medicine

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract The origin of most bacterial infections in the urinary tract is often presumed to be the gut. Herein, we investigate the relationship between the gut microbiota and future development of bacteriuria and urinary tract infection (UTI). We perform gut microbial profiling using 16S rRNA gene deep sequencing on 510 fecal specimens from 168 kidney transplant recipients and metagenomic sequencing on a subset of fecal specimens and urine supernatant specimens. We report that a 1% relative gut abundance of Escherichia is an independent risk factor for Escherichia bacteriuria and UTI and a 1% relative gut abundance of Enterococcus is an independent risk factor for Enterococcus bacteriuria. Strain analysis establishes a close strain level alignment between species found in the gut and in the urine in the same subjects. Our results support a gut microbiota–UTI axis, suggesting that modulating the gut microbiota may be a potential novel strategy to prevent UTIs.

Date: 2019
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DOI: 10.1038/s41467-019-13467-w

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