Primary decidual zone formation requires Scribble for pregnancy success in mice

Jia Yuan, Shizu Aikawa, Wenbo Deng, Amanda Bartos, Gerd Walz, Florian Grahammer, Tobias B. Huber, Xiaofei Sun and Sudhansu K. Dey ()
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Jia Yuan: Cincinnati Children’s Hospital Medical Center
Shizu Aikawa: Cincinnati Children’s Hospital Medical Center
Wenbo Deng: Cincinnati Children’s Hospital Medical Center
Amanda Bartos: Cincinnati Children’s Hospital Medical Center
Gerd Walz: University of Freiburg
Florian Grahammer: University Medical Center Hamburg-Eppendorf
Tobias B. Huber: University Medical Center Hamburg-Eppendorf
Xiaofei Sun: Cincinnati Children’s Hospital Medical Center
Sudhansu K. Dey: Cincinnati Children’s Hospital Medical Center

Nature Communications, 2019, vol. 10, issue 1, 1-10

Abstract: Abstract Scribble (Scrib) is a scaffold protein with multifunctional roles in PCP, tight junction and Hippo signaling. This study shows that Scrib is expressed in stromal cells around the implantation chamber following implantation. Stromal cells transform into epithelial-like cells to form the avascular primary decidual zone (PDZ) around the implantation chamber (crypt). The PDZ creates a permeability barrier around the crypt restricting immune cells and harmful agents from maternal circulation to protect embryonic health. The mechanism underlying PDZ formation is not yet known. We found that uterine deletion of Scrib by a Pgr-Cre driver leads to defective PDZ formation and implantation chamber (crypt) formation, compromising pregnancy success. Interestingly, epithelial-specific Scrib deletion by a lactoferrin-Cre (Ltf-Cre) driver does not adversely affect PDZ formation and pregnancy success. These findings provide evidence for a previously unknown function of stromal Scrib in PDZ formation, potentially involving ZO-1 and Hippo signaling.

Date: 2019
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DOI: 10.1038/s41467-019-13489-4

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