Programming DNA origami patterning with non-canonical DNA-based metallization reactions

Sisi Jia, Jianbang Wang, Mo Xie, Jixue Sun, Huajie Liu (), Yinan Zhang, Jie Chao, Jiang Li, Lihua Wang, Jianping Lin, Kurt V. Gothelf and Chunhai Fan ()
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Sisi Jia: Shanghai Jiao Tong University
Jianbang Wang: Chinese Academy of Sciences
Mo Xie: Chinese Academy of Sciences
Jixue Sun: Nankai University
Huajie Liu: Tongji University
Yinan Zhang: Chinese Academy of Sciences
Jie Chao: Nanjing University of Posts & Telecommunications
Jiang Li: Chinese Academy of Sciences
Lihua Wang: Chinese Academy of Sciences
Jianping Lin: Nankai University
Kurt V. Gothelf: Aarhus University
Chunhai Fan: Shanghai Jiao Tong University

Nature Communications, 2019, vol. 10, issue 1, 1-9

Abstract: Abstract The inherent specificity of DNA sequence hybridization has been extensively exploited to develop bioengineering applications. Nevertheless, the structural potential of DNA has been far less explored for creating non-canonical DNA-based reactions. Here we develop a DNA origami-enabled highly localized metallization reaction for intrinsic metallization patterning with 10-nm resolution. Both theoretical and experimental studies reveal that low-valence metal ions (Cu2+ and Ag+) strongly coordinate with DNA bases in protruding clustered DNA (pcDNA) prescribed on two-dimensional DNA origami, which results in effective attraction within flexible pcDNA strands for site-specific pcDNA condensation. We find that the metallization reactions occur selectively on prescribed sites while not on origami substrates. This strategy is generically applicable for free-style metal painting of alphabet letters, digits and geometric shapes on all−DNA substrates with near-unity efficiency. We have further fabricated single- and double-layer nanoscale printed circuit board (nano-PCB) mimics, shedding light on bio-inspired fabrication for nanoelectronic and nanophotonic applications.

Date: 2019
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DOI: 10.1038/s41467-019-13507-5

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