DNA origami cryptography for secure communication

Yinan Zhang, Fei Wang, Jie Chao, Mo Xie, Huajie Liu (), Muchen Pan, Enzo Kopperger, Xiaoguo Liu, Qian Li, Jiye Shi, Lihua Wang, Jun Hu, Lianhui Wang, Friedrich C. Simmel and Chunhai Fan ()
Additional contact information
Yinan Zhang: Shanghai Jiao Tong University
Fei Wang: Shanghai Jiao Tong University
Jie Chao: Nanjing University of Posts & Telecommunications
Mo Xie: Shanghai Institute of Applied Physics, Chinese Academy of Sciences
Huajie Liu: Tongji University
Muchen Pan: Shanghai Institute of Applied Physics, Chinese Academy of Sciences
Enzo Kopperger: Technische Universität München
Xiaoguo Liu: Shanghai Jiao Tong University
Qian Li: Shanghai Jiao Tong University
Jiye Shi: Shanghai Institute of Applied Physics, Chinese Academy of Sciences
Lihua Wang: Shanghai Institute of Applied Physics, Chinese Academy of Sciences
Jun Hu: Shanghai Institute of Applied Physics, Chinese Academy of Sciences
Lianhui Wang: Nanjing University of Posts & Telecommunications
Friedrich C. Simmel: Technische Universität München
Chunhai Fan: Shanghai Jiao Tong University

Nature Communications, 2019, vol. 10, issue 1, 1-8

Abstract: Abstract Biomolecular cryptography exploiting specific biomolecular interactions for data encryption represents a unique approach for information security. However, constructing protocols based on biomolecular reactions to guarantee confidentiality, integrity and availability (CIA) of information remains a challenge. Here we develop DNA origami cryptography (DOC) that exploits folding of a M13 viral scaffold into nanometer-scale self-assembled braille-like patterns for secure communication, which can create a key with a size of over 700 bits. The intrinsic nanoscale addressability of DNA origami additionally allows for protein binding-based steganography, which further protects message confidentiality in DOC. The integrity of a transmitted message can be ensured by establishing specific linkages between several DNA origamis carrying parts of the message. The versatility of DOC is further demonstrated by transmitting various data formats including text, musical notes and images, supporting its great potential for meeting the rapidly increasing CIA demands of next-generation cryptography.

Date: 2019
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DOI: 10.1038/s41467-019-13517-3

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