Cerebral oxygenation during locomotion is modulated by respiration

Qingguang Zhang, Morgane Roche, Kyle W. Gheres, Emmanuelle Chaigneau, Ravi T. Kedarasetti, William D. Haselden, Serge Charpak and Patrick J. Drew ()
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Qingguang Zhang: The Pennsylvania State University
Morgane Roche: Institut National de la Santé et de la Recherche Médicale
Kyle W. Gheres: The Pennsylvania State University
Emmanuelle Chaigneau: Institut National de la Santé et de la Recherche Médicale
Ravi T. Kedarasetti: The Pennsylvania State University
William D. Haselden: The Pennsylvania State University
Serge Charpak: Institut National de la Santé et de la Recherche Médicale
Patrick J. Drew: The Pennsylvania State University

Nature Communications, 2019, vol. 10, issue 1, 1-15

Abstract: Abstract In the brain, increased neural activity is correlated with increases of cerebral blood flow and tissue oxygenation. However, how cerebral oxygen dynamics are controlled in the behaving animal remains unclear. We investigated to what extent cerebral oxygenation varies during locomotion. We measured oxygen levels in the cortex of awake, head-fixed mice during locomotion using polarography, spectroscopy, and two-photon phosphorescence lifetime measurements of oxygen sensors. We find that locomotion significantly and globally increases cerebral oxygenation, specifically in areas involved in locomotion, as well as in the frontal cortex and the olfactory bulb. The oxygenation increase persists when neural activity and functional hyperemia are blocked, occurred both in the tissue and in arteries feeding the brain, and is tightly correlated with respiration rate and the phase of respiration cycle. Thus, breathing rate is a key modulator of cerebral oxygenation and should be monitored during hemodynamic imaging, such as in BOLD fMRI.

Date: 2019
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DOI: 10.1038/s41467-019-13523-5

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