Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation

Shunsuke Hasegawa, Hotaka Fukushima, Hiroshi Hosoda, Tatsurou Serita, Rie Ishikawa, Tomohiro Rokukawa, Ryouka Kawahara-Miki, Yue Zhang, Miho Ohta, Shintaro Okada, Toshiyuki Tanimizu, Sheena A. Josselyn, Paul W. Frankland and Satoshi Kida ()
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Shunsuke Hasegawa: Tokyo University of Agriculture
Hotaka Fukushima: Tokyo University of Agriculture
Hiroshi Hosoda: Tokyo University of Agriculture
Tatsurou Serita: Tokyo University of Agriculture
Rie Ishikawa: Tokyo University of Agriculture
Tomohiro Rokukawa: Tokyo University of Agriculture
Ryouka Kawahara-Miki: Tokyo University of Agriculture
Yue Zhang: Tokyo University of Agriculture
Miho Ohta: Tokyo University of Agriculture
Shintaro Okada: Tokyo University of Agriculture
Toshiyuki Tanimizu: Tokyo University of Agriculture
Sheena A. Josselyn: University of Toronto
Paul W. Frankland: University of Toronto
Satoshi Kida: Tokyo University of Agriculture

Nature Communications, 2019, vol. 10, issue 1, 1-14

Abstract: Abstract Cognitive performance in people varies according to time-of-day, with memory retrieval declining in the late afternoon-early evening. However, functional roles of local brain circadian clocks in memory performance remains unclear. Here, we show that hippocampal clock controlled by the circadian-dependent transcription factor BMAL1 regulates time-of-day retrieval profile. Inducible transgenic dominant negative BMAL1 (dnBMAL1) expression in mouse forebrain or hippocampus disrupted retrieval of hippocampal memories at Zeitgeber Time 8–12, independently of retention delay, encoding time and Zeitgeber entrainment cue. This altered retrieval profile was associated with downregulation of hippocampal Dopamine-cAMP signaling in dnBMAL1 mice. These changes included decreases in Dopamine Receptors (D1-R and D5-R) and GluA1-S845 phosphorylation by PKA. Consistently, pharmacological activation of cAMP-signals or D1/5Rs rescued impaired retrieval in dnBMAL1 mice. Importantly, GluA1 S845A knock-in mice showed similar retrieval deficits with dnBMAL1 mice. Our findings suggest mechanisms underlying regulation of retrieval by hippocampal clock through D1/5R-cAMP-PKA-mediated GluA1 phosphorylation.

Date: 2019
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DOI: 10.1038/s41467-019-13554-y

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