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A model of DNA damage response activation at stalled replication forks by SPRTN

Christopher Bruhn and Marco Foiani ()
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Christopher Bruhn: IFOM (Istituto FIRC di Oncologia Molecolare)
Marco Foiani: IFOM (Istituto FIRC di Oncologia Molecolare)

Nature Communications, 2019, vol. 10, issue 1, 1-3

Abstract: The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.

Date: 2019
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DOI: 10.1038/s41467-019-13610-7

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